Troponin T Cardiac (cTnT) Protein

Name: cTnT Protein; Troponin T Cardiac; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS664072
Price: 2225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS664072

MBS664072 is a protein targeting cTnT. Also known as Porcine cardiac troponin T (cTnT). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Troponin T Cardiac (cTnT), Protein

Full Product Name

Porcine cardiac troponin T (cTnT)

Product Gene Name

cTnT protein

Form/Format

Lyophilized from 0.01 M HCl.
Product is recommended to reconstitute with urea/Tris buffer, pH 7.5 (7 M urea, 5 mM EDTA, 15 mM mercaptoethanol, 20 mM Tris).

Preparation and Storage

At -20 degree C (-70 degree C for long term storage)

Molecular Weight

34,452 Da

Source Note

Porcine heart tissue.

Analysis

Purity > 98 % (SDS-PAGE).
Immunological identity confirmed by reaction with monoclonal antibody that is specific for the TnT cardiac isoform.

Other Notes

Small volumes of cTnT protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for cTnT. It may not necessarily be applicable to this product.

NCBI GI #

6981666

NCBI GeneID

24837

NCBI Accession #

NP_036808.1

UniProt Related Accession #

P50753

GenBank Nucleotide #

NM_012676.1

NCBI Official Full Name

troponin T, cardiac muscle

NCBI Official Synonym Full Names

troponin T type 2 (cardiac)

NCBI Official Symbol

Tnnt2

NCBI Official Synonym Symbols

Ctt; CTTG; Tnnt3; RATCTTG

UniProt Protein Name

Troponin T, cardiac muscle

UniProt Synonym Protein Names

Cardiac muscle troponin T; cTnT

Protein Family

Troponin

UniProt Gene Name

Tnnt2

UniProt Synonym Gene Names

TnTc; cTnT

UniProt Entry Name

TNNT2_RAT

NCBI Protein Information

troponin T, cardiac muscle; cTnT; tnTc; Troponin T cardiac; cardiac troponin T2; troponin T2, cardiac; cardiac muscle troponin T

NCBI Summary for cTnT

tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]

UniProt Comments for cTnT

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament

Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: actin crosslink formation; protein heterooligomerization; metabolic process; atrial cardiac muscle morphogenesis; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction

Research Articles on cTnT

1. Replacement of the functionally corresponding N-terminal end portion of rat fast skeletal cardiac muscle (RfsTnT) into cardiac muscle troponin T (RcTnT), the observed functional differences associate with a sequence variation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with cTnT protein

Products by Pathway	Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram

Diseases associated with cTnT protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>162 publications with cTnT and Cardiovascular Diseases
Heart Diseases Antibodies	>158 publications with cTnT and Heart Diseases
Cardiomyopathies Antibodies	>120 publications with cTnT and Cardiomyopathies
Cardiomyopathy, Hypertrophic Antibodies	>102 publications with cTnT and Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic, Familial Antibodies	>49 publications with cTnT and Cardiomyopathy, Hypertrophic, Familial
Cardiomyopathy, Dilated Antibodies	>46 publications with cTnT and Cardiomyopathy, Dilated
Cardiomegaly Antibodies	>41 publications with cTnT and Cardiomegaly
Hypertrophy Antibodies	>38 publications with cTnT and Hypertrophy
Heart Failure Antibodies	>36 publications with cTnT and Heart Failure
Death, Sudden, Cardiac Antibodies	>34 publications with cTnT and Death, Sudden, Cardiac

Organs/Tissues associated with cTnT protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>124 publications with cTnT and Heart
Embryonic Tissue Antibodies	>16 publications with cTnT and Embryonic Tissue
Lung Antibodies	>5 publications with cTnT and Lung
Prostate Antibodies	>2 publications with cTnT and Prostate
Connective Tissue Antibodies	>2 publications with cTnT and Connective Tissue