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CD38 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666525

Information: Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose (1). CD38 is involved in lymphocyte activation and adhesion to endothelium and has recently… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD38, Monoclonal Antibody
Full Product Name
anti-human CD38-Purified Preservative Free
Product Gene Name
anti-CD38 antibody
Product Synonym Names
Monoclonal anti-human CD38
Clonality
Monoclonal
Isotype
IgG1k
Clone Number
AT1
Host
Mouse
Species Reactivity
Human
Form/Format
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl.
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 2 - 5 degree C. Open under aseptic conditions. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
OMIM
107270
Performance
Five x 105 cultured Raji cells per tube were washed and incubated 45 minutes on ice with 80 ul of anti-CD38 antibody at 5 ug/ml. Cells were washed twice and incubated with 2°C reagent Goat anti-Mouse IgG/FITC (Catalog #MBS666783), after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.44 log10 fluorescent units when compared to a Mouse IgG1 negative control (Catalog #MBS666377).
Production
Antibody was Protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95% Immunoglobulin by SDS-PAGE and contains less than 1% Bovine Immunoglobulin. Product was 0.2 ?m filtered and vialed under aseptic conditions.
Immunogen
Human T cell tumor cells: CEM
Applications Tested/Suitable for anti-CD38 antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD38 antibody

Mouse Anti-CD38 Monoclonal Antibody – Cat# MBS666525

Testing Data of anti-CD38 antibody

Mouse Anti-CD38 Monoclonal Antibody, Testing Data – Cat# MBS666525

Product References and Citations for anti-CD38 antibody

1.) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 151-157. 2.) S. Deaglio, et al, (1998) J Immunol 160:395-402.

Other Notes

Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD38 purchase

MBS666525 is an antibody targeting CD38. Also known as anti-human CD38-Purified Preservative Free. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.

NCBI GI #
1911103
NCBI GeneID
952
NCBI Accession #
BAA18966.1
UniProt Secondary Accession #
O00121; O00122; Q96HY4
UniProt Related Accession #
P28907
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
T10; ADPRC 1
UniProt Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38
UniProt Synonym Gene Names
ADPRC 1; cADPr hydrolase 1
UniProt Entry Name
CD38_HUMAN
NCBI Protein Information
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

NCBI Summary for CD38

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]

UniProt Comments for CD38

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 3.2.2.6; Lyase; EC 2.4.99.20; Cell surface; Hydrolase; Apoptosis; Membrane protein, integral; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis
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Research Articles on CD38

1. results demonstrate that CD38(+) cells are a useful model to study effects of the cellular NAD levels on cellular processes and establish a new linker between cellular NAD levels and oxidative stress

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD38 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >1133 publications with CD38 and CD4
 CD27 antibody  >243 publications with CD38 and CD27
 IL6 antibody  >26 publications with CD38 and IL6
 LCK antibody  >8 publications with CD38 and LCK
 BST1 antibody  >3 publications with CD38 and BST1

Pathways associated with anti-CD38 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with anti-CD38 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >427 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >251 publications with CD38 and Inflammation
 Necrosis Antibodies  >197 publications with CD38 and Necrosis
 Liver Diseases Antibodies  >96 publications with CD38 and Liver Diseases
 Nervous System Diseases Antibodies  >92 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >91 publications with CD38 and Anemia
 Neoplasms, Experimental Antibodies  >76 publications with CD38 and Neoplasms, Experimental
 Carcinoma Antibodies  >60 publications with CD38 and Carcinoma
 Breast Neoplasms Antibodies  >43 publications with CD38 and Breast Neoplasms
 Pain Antibodies  >31 publications with CD38 and Pain

Organs/Tissues associated with anti-CD38 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3662 publications with CD38 and Blood
 Bone Marrow Antibodies  >1346 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >278 publications with CD38 and Lymph Node
 Liver Antibodies  >214 publications with CD38 and Liver
 Lymph Antibodies  >206 publications with CD38 and Lymph
 Spleen Antibodies  >159 publications with CD38 and Spleen
 Muscle Antibodies  >130 publications with CD38 and Muscle
 Brain Antibodies  >116 publications with CD38 and Brain
 Tonsil Antibodies  >112 publications with CD38 and Tonsil
 Pharynx Antibodies  >106 publications with CD38 and Pharynx
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