Ltbetar (LTBR) Human Protein

Name: LTBR Protein; Ltbetar; Human; MyBioSource
Brand: MyBioSource
SKU: MBS666827
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666827

Information: Human Lymphotoxin beta receptor (LTbR, TNFSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary… More details

$605 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LTbetaR (Ltbr), Protein

Full Product Name

LTbetaR-muIg-Purified Preservative Free

Product Gene Name

Ltbr protein

Product Synonym Names

Human LTbR-muIg Fusion Protein

Host

CHO cells

Species Reactivity

Human

Form/Format

50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl

Purity/Purification

Purified Preservative Free

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

Store at 2 - 5 degree C. Open under aseptic conditions. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.

Molecular Weight

44,956 Da

Molecular Structure

A soluble fusion protein consisting of 10 residual amino acids from murine CD8 alpha leader sequence (KPQAPELRGS), followed by the mature extracellular (192aa) domain of human LTbR (SQPQAVP….PLEPLPP) fused to (233aa) murine IgG2a Fc (EPRGPTI….FSRTPGK). Predicted non glycosylated molecular weight of 48.9 kd.

Transfectant Cell Line

CHO

Performance

LTbR-muIg identity was confirmed by n-terminal sequencing (KPQAP) and amino acid analysis. LTbR-muIg was detectable in EIA (at 50-500 ng/ml) using recombinant human LIGHT coated plate for capture and GAM/HRP as a detector.

Production

Recombinant protein from (low FBS containing) tissue culture supernatant of transfectants was purified using affinity and size exclusion chromatography. Product was 0.2u sterile-filtered and vialed under aseptic conditions

Buffer

50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl. Product was sterile filtered under aseptic conditions.

Applications Tested/Suitable for Ltbr protein

ELISA (EIA)

Product References and Citations for Ltbr protein

1) T W Mak, M E Saunders eds. The Immune Response 2006 Elsevier Academic Press p 499. 2) J L Browning, R.A. Fava, et al. Immunity (2005) 23(5): 539-50. 3)Y Wang, Y Fu, et al. J Immunol (2005) 175: 6997-7002. 4)P Stopfer, T Hehlgans, et al. J Immunol (2004) 172: 7459-7465. 5) Gommermann J, JL Browning, et al, Nat Rev Immunol (2003) 3:642-655. 6) Spahn TW, T Kucharzik, et al. Infection and Immunity (2005) 73(11): 7077-7088.

Other Notes

Small volumes of Ltbr protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ltbr purchase

MBS666827 is a protein targeting Ltbr. Also known as LTbetaR-muIg-Purified Preservative Free. Reactive in Human. Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for Ltbr. It may not necessarily be applicable to this product.

NCBI GI #

187953983

NCBI GeneID

17000

NCBI Accession #

AAI38592.1

UniProt Related Accession #

P50284

NCBI Official Full Name

Lymphotoxin B receptor

NCBI Official Synonym Full Names

lymphotoxin B receptor

NCBI Official Symbol

Ltbr

NCBI Official Synonym Symbols

CD18; Ltar; TNFCR; Tnfbr; TNFRrp; LTbetaR; TNFR-RP; Tnfrsf3; AI256028; TNFR2-RP; TNF-R-III

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 3

UniProt Synonym Protein Names

Lymphotoxin-beta receptor

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

Ltbr

UniProt Synonym Gene Names

Tnfcr; Tnfrsf3

UniProt Entry Name

TNR3_MOUSE

NCBI Protein Information

tumor necrosis factor receptor superfamily member 3; LT beta-R; LT-beta receptor; lymphotoxin-beta receptor; TNF receptor-related protein; tumor necrosis factor receptor superfamily, member 3

UniProt Comments for Ltbr

LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; lymph node development

Research Articles on Ltbr

1. M1 macrophages as inducer cells that trigger the expression of chemokines by vascular smooth muscle cell independently of lymphotoxin beta receptor signalling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ltbr protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Viral Carcinogenesis Pathway antibodies	Viral Carcinogenesis Pathway Diagram
Viral Carcinogenesis Pathway antibodies	Viral Carcinogenesis Pathway Diagram

Diseases associated with Ltbr protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>181 publications with Ltbr and Necrosis
Inflammation Antibodies	>35 publications with Ltbr and Inflammation
Nervous System Diseases Antibodies	>13 publications with Ltbr and Nervous System Diseases
Neoplasms, Experimental Antibodies	>6 publications with Ltbr and Neoplasms, Experimental
Liver Diseases Antibodies	>6 publications with Ltbr and Liver Diseases
Breast Neoplasms Antibodies	>5 publications with Ltbr and Breast Neoplasms
Liver Neoplasms Antibodies	>4 publications with Ltbr and Liver Neoplasms
Weight Loss Antibodies	>3 publications with Ltbr and Weight Loss
Prostatic Diseases Antibodies	>3 publications with Ltbr and Prostatic Diseases
Malaria Antibodies	>3 publications with Ltbr and Malaria

Organs/Tissues associated with Ltbr protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>47 publications with Ltbr and Spleen
Bone Antibodies	>39 publications with Ltbr and Bone
Bone Marrow Antibodies	>24 publications with Ltbr and Bone Marrow
Intestine Antibodies	>21 publications with Ltbr and Intestine
Thymus Antibodies	>20 publications with Ltbr and Thymus
Embryonic Tissue Antibodies	>20 publications with Ltbr and Embryonic Tissue
Liver Antibodies	>14 publications with Ltbr and Liver
Skin Antibodies	>11 publications with Ltbr and Skin
Lung Antibodies	>6 publications with Ltbr and Lung
Eye Antibodies	>6 publications with Ltbr and Eye