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Dectin-2 (CLEC6A) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668001

Dectin-2 (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domainfold. Dectin-2 plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It… More details

$215 / 0.025 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Dectin-2 (CLEC6A), Monoclonal Antibody
Full Product Name
Dectin-2 Monoclonal Antibody
Product Gene Name
anti-CLEC6A antibody
Product Synonym Names
CLEC6A,CLECSF10,DECTIN2
Clonality
Monoclonal
Isotype
Mouse IgG2a, Kappa
Clone Number
ABM2H28
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Purified ; 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Protein G Chromatography
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store antibody at 4 degree C. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
OMIM
613579
3D Structure
ModBase 3D Structure for Q6EIG7
Immunogen
A partial length recombinant Dectin-2 protein (ammino acids 70-230) was used as the immunogen for this antibody

Product Categories/Family for anti-CLEC6A antibody

Immunology
Applications Tested/Suitable for anti-CLEC6A antibody
Western Blot (WB), Flow Cytometry (FC), Immunohistochemistry (IHC)
Application Notes for anti-CLEC6A antibody
WB: 2-4ug/ml
FC: 0.5ug/106 cells
IHC: 5ug/ml

Western Blot (WB) of anti-CLEC6A antibody

Expression analysis of Dectin 2 Anti- Dectin 2 antibody (Clone: ABM2H28) was used at 2 ug/ml on Raw lysate.
Mouse Anti-CLEC6A Monoclonal Antibody – Cat# MBS668001

Flow Cytometry (FC) of anti-CLEC6A antibody

Intracellular flow analysis of Dectin-2 in human PBMC (Lymphocytes) using 0.5 ug/10^6 cells of Dectin-2 antibody (Clone: ABM2H28). Green represents isotype control; red represents anti-Dectin-2 antibody. Goat anti-mouse PE conjugate was used as secondary.
Mouse Anti-CLEC6A Monoclonal Antibody, Flow Cytometry (FC) – Cat# MBS668001

Immunohistochemistry (IHC) of anti-CLEC6A antibody

Immunohistochemical analysis of Dectin-2 in Renal Cell Carcinoma using Dectin-2 antibody (Clone: ABM2H28) at 5 ug/ml.
Mouse Anti-CLEC6A Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS668001

Other Notes

Small volumes of anti-CLEC6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC6A purchase

MBS668001 is an antibody targeting CLEC6A. Also known as Dectin-2 Monoclonal Antibody. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC6A. It may not necessarily be applicable to this product.

NCBI GI #
55742774
NCBI GeneID
93978
NCBI Accession #
NP_001007034.1
UniProt Primary Accession #
Q6EIG7
UniProt Secondary Accession #
A2RUK3
UniProt Related Accession #
Q6EIG7
GenBank Nucleotide #
NM_001007033.1
NCBI Official Full Name
C-type lectin domain family 6 member A
NCBI Official Synonym Full Names
C-type lectin domain family 6, member A
NCBI Official Symbol
CLEC6A
NCBI Official Synonym Symbols
CLEC4N; CLECSF10
UniProt Protein Name
C-type lectin domain family 6 member A
UniProt Synonym Protein Names
C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC6A
UniProt Synonym Gene Names
CLECSF10; DECTIN2; DC-associated C-type lectin 2; Dectin-2
UniProt Entry Name
CLC6A_HUMAN
NCBI Protein Information
C-type lectin domain family 6 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; dectin-2; dendritic cell-associated C-type lectin 2

NCBI Summary for CLEC6A

Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
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UniProt Comments for CLEC6A

dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to membrane

Molecular Function: carbohydrate binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; defense response to fungus; positive regulation of cytokine secretion
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Research Articles on CLEC6A

1. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CLEC6A antibody

 Products by Pathway  Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 Dectin-2 Family Pathway antibodies  Dectin-2 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
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