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CD11b Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668341

MBS668341 is an antibody targeting CD11b. Also known as Monoclonal Antibody to h/m CD11b (Clone: M1/70). Reactive in Human. Host: Rat. More details

$205 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD11b, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to h/m CD11b (Clone: M1/70)
Product Gene Name
anti-CD11b antibody
Product Synonym Gene Name
Itgam
Product Synonym Names
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpham; Leukocyte adhesion receptor MO1
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
M1/70
Host
Rat
Species Reactivity
Human
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Purity/Purification
Purified
Protein G Chromatography
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Molecular Weight
115,196 Da
3D Structure
ModBase 3D Structure for P05555
Immunogen Information
B10 mouse spleen cells enrichedfor T lymphocytes were used as immunogen for this antibody.
Antigen
CD11b

Product Categories/Family for anti-CD11b antibody

Antibodies; Immunology
Applications Tested/Suitable for anti-CD11b antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD11b antibody
Flow Cytometry: 0.5-1 ug/10^6 cells

Flow Cytometry (FC/FACS) of anti-CD11b antibody

Fig-1: Cell Surface flow analysis of h/mCD11b in PBMC (Lymphocyte gated) using 0.5 ug/10^6 cells. Green represents isotype control; red represents anti-h/mCD11b antibody. Goat anti-rat PE conjugated secondary antibody was used.
Rat Anti-CD11b Monoclonal Antibody – Cat# MBS668341

Other Notes

Small volumes of anti-CD11b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD11b. It may not necessarily be applicable to this product.

NCBI GI #
124956
NCBI GeneID
16409
NCBI Accession #
P05555.2
UniProt Primary Accession #
P05555
UniProt Secondary Accession #
Q8CA73
UniProt Related Accession #
P05555
NCBI Official Full Name
Integrin alpha-M
NCBI Official Synonym Full Names
integrin alpha M
NCBI Official Symbol
Itgam
NCBI Official Synonym Symbols
CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik
UniProt Protein Name
Integrin alpha-M
UniProt Synonym Protein Names
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b
Protein Family
Integrin
UniProt Gene Name
Itgam
NCBI Protein Information
integrin alpha-M

UniProt Comments for CD11b

ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7|7 F3

Cellular Component: cell surface; external side of plasma membrane; extracellular space; integral to membrane; nucleus

Molecular Function: glycoprotein binding; heparan sulfate proteoglycan binding; heparin binding; opsonin binding; protein heterodimerization activity

Biological Process: activated T cell proliferation; cell adhesion; cell-cell adhesion; cellular extravasation; leukocyte adhesion; leukocyte migration during inflammatory response; microglia development; neutrophil chemotaxis
Show more

Research Articles on CD11b

1. protective role in glomerulonephritis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD11b antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Organs/Tissues associated with anti-CD11b antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4438 publications with CD11b and Blood
 Bone Marrow Antibodies  >767 publications with CD11b and Bone Marrow
 Brain Antibodies  >612 publications with CD11b and Brain
 Lung Antibodies  >526 publications with CD11b and Lung
 Spleen Antibodies  >505 publications with CD11b and Spleen
 Skin Antibodies  >241 publications with CD11b and Skin
 Heart Antibodies  >202 publications with CD11b and Heart
 Spinal Cord Antibodies  >162 publications with CD11b and Spinal Cord
 Intestine Antibodies  >154 publications with CD11b and Intestine
 Eye Antibodies  >146 publications with CD11b and Eye
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