Mouse Anti-TIMP-4 Monoclonal Antibody – Cat# MBS670157

TIMP-4 Antibody – Mouse Monoclonal

Name: TIMP-4 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS670157
Price: 555 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670157

MBS670157 is an antibody targeting TIMP-4. Also known as Mouse Anti-Human TIMP-4-HRP. Reactive in Human. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TIMP-4, Monoclonal Antibody

Full Product Name

Mouse Anti-Human TIMP-4-HRP

Product Gene Name

anti-TIMP-4 antibody

Product Synonym Names

Mouse Anti-Human TIMP-4 - HRP; Mouse Anti-Human TIMP-4

Clonality

Monoclonal

Isotype

Mouse IgG2a

Clone Number

SB30c

Host

Mouse

Species Reactivity

Human

Form/Format

Horseradish Peroxidase (HRP) Conjugate

Specificity

Human TIMP-4
Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (~23kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP- 2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7. 1-9

Preparation and Storage

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C.
The horseradish peroxidase (HRP) conjugate is supplied as 1.0 mL of stock solution in 50% glycerol/50% PBS, pH 7.4. No preservative added. Store at 2-8 degree C or long-term at -20 degree C.
Reagents are stable for the period shown on the label if stored as directed.

Immunogen

Recombinant TIMP-4

Characterization

To insure lot-to-lot consistency, each batch of product is tested by IHC to conform with the characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-TIMP-4 antibody

Immunohistochemistry (Frozen Sections); Western Blot

Product References and Citations for anti-TIMP-4 antibody

1. Greene, J., M. Wang, Y.E. Liu, L.A. Raymond, C. Rosen, and Y.E. Shi. 1996. J. Biol. Chem. 271:30375.
2. Liu, Y.E., M. Wang, J. Greene, J. Su, S. Ullrich, H. Li, S. Sheng, P. Alexander, Q.A. Sang, and Y.E. Shi. 1997. J. Biol. Chem. 272:20479.
3. Chesler, L., D.W. Golde, N. Bersch, and M.D. Johnson. 1995. Blood 86:4506.
4. Stetler-Stevenson, W.G., N. Bersch, and D.W. Golde. 1992. FEBS Lett. 296:231.
5. Corcoran, M.L., and W.G. Stetler-Stevenson. 1995. J. Biol. Chem. 270:13453.
6. Hayakawa, T., K. Yamashita, E. Ohuchi, and A. Shinagawa. 1994. J. Cell Sci. 107:2373.
7. Leco, K.J., S.S. Apte, G.T. Taniguchi, S.P. Hawkes, R. Khokha, G.A. Schultz, and D.R. Edwards. 1997. FEBS Lett. 401:213.
8. Dollery, C.M., J.R. McEwan, M. Wang, Q.A. Sang, Y.E. Liu, and E. Shi. 1999. Circ. Res. 84:498.
9. Tummalapalli, C.M., B.J. Heath, and S.C. Tyagi. 2001. J. Cell. Biochem. 80:512.

Other Notes

Small volumes of anti-TIMP-4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TIMP-4. It may not necessarily be applicable to this product.

NCBI GI #

6572670

NCBI GeneID

396774

NCBI Official Full Name

tissue inhibitor of metalloproteinase-4

NCBI Official Symbol

TIMP-4

Protein Family

Metalloproteinase inhibitor

NCBI Protein Information

tissue inhibitor of metalloproteinase-4

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-TIMP-4 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>13 publications with TIMP-4 and Bone
Connective Tissue Antibodies	>4 publications with TIMP-4 and Connective Tissue
Heart Antibodies	>3 publications with TIMP-4 and Heart
Muscle Antibodies	>3 publications with TIMP-4 and Muscle
Brain Antibodies	>3 publications with TIMP-4 and Brain
Vascular Antibodies	>2 publications with TIMP-4 and Vascular
Embryonic Tissue Antibodies	>2 publications with TIMP-4 and Embryonic Tissue
Ear Antibodies	>1 publications with TIMP-4 and Ear
Kidney Antibodies	>1 publications with TIMP-4 and Kidney
Umbilical Cord Antibodies	>1 publications with TIMP-4 and Umbilical Cord