CD117 Antibody – Rat Monoclonal

Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.

1. Broudy, V.C., et al, 1996. Blood 88:75.
2. Veiby, O.P., S. D. Lyman and S. E. Jacobsen. 1996. Blood 87:3117.
3. Sudo, T., et al. 1995. Oncogene 11:2469.
4. Yoshida, H., et al. 1996. Development 122: 1207.

Small volumes of anti-CD117/c-Kit antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS673627 is an antibody targeting CD117/c-Kit. Also known as Rat Anti-Mouse CD117/c-kit-FITC. Reactive in Mouse. Host: Rat.