Gamma Delta (TCR) Antibody – Mouse Monoclonal

The monoclonal antibody TCR-1 precipitates a heterodimer of Mr 90 kDa (two bands of Mr 50 kDa and 40 kDa upon reduction) on chicken peripheral blood T cells. Deglycosylation of the heterodimer yields two polypeptides of Mr 35 kDa and 32 kDa. Unlike human and mouse in which yo cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of yo T cells. The frequency of TCRgamma/delta cells is typically 20-25% of the total blood T cells but may reach approximately 50% in chickens of six- months of age. The majority of TCRgamma/delta+ cells in the thymus and blood are CD4-CD8- although a small subset of them may express CD8 or CD4 coreceptors. However, when the TCRgamma/delta+ cells migrate into the spleen and intestine most of them begin to express CD8. Although the biological function of yo T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ yo T cells may also be involved in down-regulation of the immune response. They cannot, however, induce a graft-vs-host (GVH) reactions.

1. Sowder, J.T., C.-L. Chen, L.L. Ager, M.M. Chan, and M.D. Cooper. 1988. J. Exp. Med. 167:315.
2. Chen, C.H., J. Cihak, U. Losch, and M.D. Cooper. 1988. Eur. J. Immunol. 18:539
3. Quere, P., M.D. Cooper, and G.J. Thorbecke. 1990. Immunology 71:517.
4. Chen, C.H., T.W.F. Gobel, T. Kubota, and M.D. Cooper. 1993. 1994. Poultry Science 73:1012.
5. Chen, C.-L. 1996. Personal communication.
6. Sowder, J.T., C.H. Chen, L.L. Ager, J. Cihak, U. Losch, and M.D. Cooper. 1988b. Fed. Proc. 2:874.
7. Cihak, J., U. Losch, G. Hoffman-Hezer, C.H. Chen, M.D. Cooper, and H.W.L. Ziegler-Heitbrock. 1993. Scand. J. Immunol. 38:123.

Small volumes of anti-TCR gamma delta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS673877 is an antibody targeting TCR gamma delta. Also known as Mouse Anti-Chicken TCRgd-BIOT. Reactive in Chicken. Host: Mouse.