Mouse Anti-CXCL2 Monoclonal Antibody – Cat# MBS690043

CXCL2 Antibody – Mouse Monoclonal

Name: CXCL2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690043
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690043

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant human GRO-beta is a 7.9 kDa protein consisting of 73 amino acids including the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CXCL2, Monoclonal Antibody

Full Product Name

Mouse Anti-Human CXCL2

Product Gene Name

anti-CXCL2 antibody

Product Synonym Names

CXCL2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(11B27)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

11,389 Da

Chromosome Location

Chromosome: 4; NC_000004.12 (74097035..74099280, complement). Location: 4q21

OMIM

139110

3D Structure

ModBase 3D Structure for P19875

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant CXCL2 (also called GROb).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CXCL2 antibody

Western Blot (WB), Neutr

Other Notes

Small volumes of anti-CXCL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL2 purchase

MBS690043 is an antibody targeting CXCL2. Also known as Mouse Anti-Human CXCL2. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL2. It may not necessarily be applicable to this product.

NCBI GI #

4504155

NCBI GeneID

2920

NCBI Accession #

NP_002080.1

UniProt Primary Accession #

P19875

UniProt Secondary Accession #

Q6FGD6; Q9UPB8

UniProt Related Accession #

P19875

GenBank Nucleotide #

NM_002089.3

NCBI Official Full Name

C-X-C motif chemokine 2

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 2

NCBI Official Symbol

CXCL2

NCBI Official Synonym Symbols

GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

UniProt Protein Name

C-X-C motif chemokine 2

UniProt Synonym Protein Names

Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alphaCleaved into the following chain:GRO-beta(5-73); Alternative name(s):; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL2

UniProt Synonym Gene Names

GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF

UniProt Entry Name

CXCL2_HUMAN

NCBI Protein Information

C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta

NCBI Summary for CXCL2

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

UniProt Comments for CXCL2

Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Ref.9

Subcellular location: Secreted.

Post-translational modification: The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Pharmaceutical use: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Research Articles on CXCL2

1. our results demonstrate the diverse mechanisms by which CXCL2 and CXCL3 mediate normal and asthmatic airway smooth muscle cell migration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL2 antibody

Reference Product	PubMed Publications
CXCL1 antibody	>507 publications with CXCL2 and CXCL1
CCL4 antibody	>181 publications with CXCL2 and CCL4
CXCR2 antibody	>140 publications with CXCL2 and CXCR2
CCL5 antibody	>109 publications with CXCL2 and CCL5
CXCL3 antibody	>86 publications with CXCL2 and CXCL3
CCL20 antibody	>65 publications with CXCL2 and CCL20
CCR1 antibody	>23 publications with CXCL2 and CCR1
CXCR1 antibody	>21 publications with CXCL2 and CXCR1
CCR5 antibody	>20 publications with CXCL2 and CCR5
CCL19 antibody	>6 publications with CXCL2 and CCL19

Pathways associated with anti-CXCL2 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CXCL2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>925 publications with CXCL2 and Inflammation
Necrosis Antibodies	>611 publications with CXCL2 and Necrosis
Lung Diseases Antibodies	>368 publications with CXCL2 and Lung Diseases
Disease Models, Animal Antibodies	>327 publications with CXCL2 and Disease Models, Animal
Lung Injury Antibodies	>250 publications with CXCL2 and Lung Injury
Pneumonia Antibodies	>168 publications with CXCL2 and Pneumonia
Reperfusion Injury Antibodies	>113 publications with CXCL2 and Reperfusion Injury
Neoplasms Antibodies	>104 publications with CXCL2 and Neoplasms
Wounds and Injuries Antibodies	>91 publications with CXCL2 and Wounds and Injuries
Edema Antibodies	>86 publications with CXCL2 and Edema

Organs/Tissues associated with anti-CXCL2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1001 publications with CXCL2 and Blood
Lung Antibodies	>600 publications with CXCL2 and Lung
Liver Antibodies	>190 publications with CXCL2 and Liver
Bone Antibodies	>148 publications with CXCL2 and Bone
Bone Marrow Antibodies	>126 publications with CXCL2 and Bone Marrow
Brain Antibodies	>112 publications with CXCL2 and Brain
Intestine Antibodies	>104 publications with CXCL2 and Intestine
Kidney Antibodies	>95 publications with CXCL2 and Kidney
Eye Antibodies	>50 publications with CXCL2 and Eye
Lymph Node Antibodies	>40 publications with CXCL2 and Lymph Node