UNC5H3 Antibody – Mouse Monoclonal

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand

By similarity.

Subunit structure: Interacts with the cytoplasmic part of DCC

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. Ref.1

Post-translational modification: Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent

By similarity.Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis

By similarity.

Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

Sequence similarities: Belongs to the unc-5 family.Contains 1 death domain.Contains 1 Ig-like (immunoglobulin-like) domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 2 TSP type-1 domains.Contains 1 ZU5 domain.