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IL-15 receptor alpha Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690235

Interleukin 15 receptor alpha (IL-15 R alpha) is a high affinity receptor that specifically binds IL-15 and associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. IL-15 R… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
IL-15 receptor alpha, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse IL-15 receptor alpha
Product Gene Name
anti-IL-15 receptor alpha antibody
Product Synonym Names
Anti-mouse Interleukin-15 Receptor alpha [IL-15Ralpha] (#6C38)
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(6C38)
Host
Rat
Species Reactivity
Mouse
Form/Format
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at
Purity/Purification
Protein A/G affinity chromatography
Specificity
This antibody detects mouse IL-15Ralpha in Western blotting.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Molecular Weight
28,061 Da
Chromosome Location
Chromosome: 2; NC_000068.7 (11705169..11733985). Location: 2 A1; 2 8.97 cM
3D Structure
ModBase 3D Structure for Q60819
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-15R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-IL-15 receptor alpha antibody
Western Blot (WB)
Application Notes for anti-IL-15 receptor alpha antibody
1. Western blot: Yes (1:500-1000)

Other Notes

Small volumes of anti-IL-15 receptor alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-15 receptor alpha purchase

MBS690235 is an antibody targeting IL-15 receptor alpha. Also known as Rat Anti-Mouse IL-15 receptor alpha. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-15 receptor alpha. It may not necessarily be applicable to this product.

NCBI GI #
407970978
NCBI GeneID
16169
NCBI Accession #
NP_001258426.1
UniProt Primary Accession #
Q60819
UniProt Secondary Accession #
Q80Z90; Q80Z91; Q80Z92; Q8R5E4; A2AP35; A2AP36; A2AP37
UniProt Related Accession #
Q60819
GenBank Nucleotide #
NM_001271497.1
NCBI Official Full Name
interleukin-15 receptor subunit alpha isoform 2
NCBI Official Synonym Full Names
interleukin 15 receptor, alpha chain
NCBI Official Symbol
Il15ra
NCBI Official Synonym Symbols
IL-15RA; AA690181
UniProt Protein Name
Interleukin-15 receptor subunit alpha
Protein Family
Interleukin-1 receptor
UniProt Gene Name
Il15ra
UniProt Synonym Gene Names
IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA
UniProt Entry Name
I15RA_MOUSE
NCBI Protein Information
interleukin-15 receptor subunit alpha; IL-15R-alpha; IL-15 receptor subunit alpha

UniProt Comments for IL-15 receptor alpha

Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction involves SYK

By similarity. Ref.5 Ref.8

Subunit structure: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates. Interacts with SYK

By similarity. Ref.1 Ref.5

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity. Nucleus membrane; Single-pass type I membrane protein

By similarity Ref.5. Soluble interleukin-15 receptor subunit alpha: Secreted › extracellular space

By similarity Ref.5.

Tissue specificity: Widely expressed. Ref.1 Ref.2

Post-translational modification: Phosphorylated by activated SYK

By similarity.N-glycosylated and O-glycosylated

By similarity. Ref.5A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE. It also binds IL15 and thus interferes with IL15 binding to the membrane receptor

By similarity.

Sequence similarities: Contains 1 Sushi (CCP/SCR) domain.
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Research Articles on IL-15 receptor alpha

1. we found that aging-related functional NK cell deficiency was completely reversed by injecting soluble IL-15/IL-15Ralpha complexes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL-15 receptor alpha antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL-15 receptor alpha antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >25 publications with IL-15 receptor alpha and Necrosis
 Inflammation Antibodies  >20 publications with IL-15 receptor alpha and Inflammation
 Neoplasms, Experimental Antibodies  >5 publications with IL-15 receptor alpha and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >3 publications with IL-15 receptor alpha and Cardiovascular Diseases
 Vascular Diseases Antibodies  >3 publications with IL-15 receptor alpha and Vascular Diseases
 Prostatic Diseases Antibodies  >3 publications with IL-15 receptor alpha and Prostatic Diseases
 Nervous System Diseases Antibodies  >3 publications with IL-15 receptor alpha and Nervous System Diseases
 Hyperplasia Antibodies  >3 publications with IL-15 receptor alpha and Hyperplasia
 Hypertrophy Antibodies  >2 publications with IL-15 receptor alpha and Hypertrophy
 Liver Diseases Antibodies  >2 publications with IL-15 receptor alpha and Liver Diseases

Organs/Tissues associated with anti-IL-15 receptor alpha antibody

 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >18 publications with IL-15 receptor alpha and Spleen
 Bone Marrow Antibodies  >18 publications with IL-15 receptor alpha and Bone Marrow
 Lung Antibodies  >13 publications with IL-15 receptor alpha and Lung
 Thymus Antibodies  >12 publications with IL-15 receptor alpha and Thymus
 Intestine Antibodies  >11 publications with IL-15 receptor alpha and Intestine
 Skin Antibodies  >8 publications with IL-15 receptor alpha and Skin
 Liver Antibodies  >6 publications with IL-15 receptor alpha and Liver
 Brain Antibodies  >5 publications with IL-15 receptor alpha and Brain
 Prostate Antibodies  >3 publications with IL-15 receptor alpha and Prostate
 Kidney Antibodies  >2 publications with IL-15 receptor alpha and Kidney
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