Rat Anti-GDF-5 Monoclonal Antibody – Cat# MBS690704

GDF-5 Antibody – Rat Monoclonal

Name: GDF-5 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690704
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690704

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GDF-5, Monoclonal Antibody

Full Product Name

Rat Anti-Mouse GDF-5

Product Gene Name

anti-GDF-5 antibody

Product Synonym Names

Gdf5; bp; brp; Cdmp-1

Clonality

Monoclonal

Isotype

IgG2

Clone Number

(13J15)

Host

Rat

Species Reactivity

Mouse

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

54,895 Da

Chromosome Location

Chromosome: 2; NC_000068.7 (155941023..155945364, complement). Location: 2 H1; 2 77.26 cM

3D Structure

ModBase 3D Structure for P43027

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of GDF-5 (growth differentiation factor 5).

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-GDF-5 antibody

Western Blot (WB), Neutr

Other Notes

Small volumes of anti-GDF-5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF-5 purchase

MBS690704 is an antibody targeting GDF-5. Also known as Rat Anti-Mouse GDF-5. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF-5. It may not necessarily be applicable to this product.

NCBI GI #

224922797

NCBI GeneID

14563

NCBI Accession #

NP_032135.2

UniProt Primary Accession #

P43027

UniProt Secondary Accession #

A2ARK2

UniProt Related Accession #

P43027

GenBank Nucleotide #

NM_008109.2

NCBI Official Full Name

growth/differentiation factor 5

NCBI Official Synonym Full Names

growth differentiation factor 5

NCBI Official Symbol

Gdf5

NCBI Official Synonym Symbols

bp; brp; Cdmp-1

UniProt Protein Name

Growth/differentiation factor 5

Protein Family

Growth/differentiation factor

UniProt Gene Name

Gdf5

UniProt Synonym Gene Names

Bp; Gdf-5; GDF-5

UniProt Entry Name

GDF5_MOUSE

NCBI Protein Information

growth/differentiation factor 5; GDF-5; brachypodism; cartilage-derived morphogenetic protein-1

UniProt Comments for GDF-5

Function: Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B

By similarity.

Subunit structure: Homodimer; disulfide-linked

By similarity. Interacts with serine proteases, HTRA1 and HTRA3. Ref.5 Ref.6

Subcellular location: Secreted

By similarity.

Involvement in disease: Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton.

Sequence similarities: Belongs to the TGF-beta family.

Research Articles on GDF-5

1. apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are sensitive to the level of endogenous GDF5 synthesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GDF-5 antibody

Reference Product	PubMed Publications
Bmpr1a antibody	>34 publications with GDF-5 and Bmpr1a
Bmpr2 antibody	>24 publications with GDF-5 and Bmpr2
Bmpr1b antibody	>21 publications with GDF-5 and Bmpr1b
Nog antibody	>11 publications with GDF-5 and Nog
Smad5 antibody	>6 publications with GDF-5 and Smad5
Barx2 antibody	>2 publications with GDF-5 and Barx2
Htra1 antibody	>1 publications with GDF-5 and Htra1

Pathways associated with anti-GDF-5 antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Molecules Associated With Elastic Fibres Pathway antibodies	Molecules Associated With Elastic Fibres Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with anti-GDF-5 antibody

Disease Name	Pubmed Publications
Osteoarthritis Antibodies	>73 publications with GDF-5 and Osteoarthritis
Disease Models, Animal Antibodies	>38 publications with GDF-5 and Disease Models, Animal
Brachydactyly type C Antibodies	>13 publications with GDF-5 and Brachydactyly type C
Necrosis Antibodies	>12 publications with GDF-5 and Necrosis
Inflammation Antibodies	>10 publications with GDF-5 and Inflammation
Movement Disorders Antibodies	>10 publications with GDF-5 and Movement Disorders
Pain Antibodies	>9 publications with GDF-5 and Pain
Brachydactyly type A2 Antibodies	>8 publications with GDF-5 and Brachydactyly type A2
Heart Diseases Antibodies	>5 publications with GDF-5 and Heart Diseases
Cardiovascular Diseases Antibodies	>5 publications with GDF-5 and Cardiovascular Diseases

Organs/Tissues associated with anti-GDF-5 antibody

Organ/Tissue Name	Pubmed Publications
Joint Antibodies	>157 publications with GDF-5 and Joint
Other Antibodies	>95 publications with GDF-5 and Other
Embryonic Tissue Antibodies	>51 publications with GDF-5 and Embryonic Tissue
Brain Antibodies	>23 publications with GDF-5 and Brain
Inner Ear Antibodies	>2 publications with GDF-5 and Inner Ear
Salivary Gland Antibodies	>2 publications with GDF-5 and Salivary Gland
Dorsal Root Ganglion Antibodies	>2 publications with GDF-5 and Dorsal Root Ganglion