INTERFERON alpha/beta R2 Antibody – Rat Monoclonal

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Ref.1 Ref.3 Ref.4 Ref.13 Ref.14

Subunit structure: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. Ref.4 Ref.11 Ref.12

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein Ref.1 Ref.4. Isoform 2: Membrane; Single-pass type I membrane protein Ref.1 Ref.4. Isoform 3: Secreted Ref.1 Ref.4.

Tissue specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. Ref.1 Ref.2 Ref.4

Post-translational modification: Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. Ref.4 Ref.13 Ref.14Glycosylated. Ref.1

Polymorphism: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [

MIM:610424].

Sequence similarities: Belongs to the type II cytokine receptor family.