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CD54 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2558142

CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important… More details

$180 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD54, Monoclonal Antibody
Full Product Name
Anti-Mouse CD54 Monoclonal Antibody (PE/Cyanine7 Conjugated) [YN1/1.7.4]
Product Gene Name
anti-CD54 antibody
Product Synonym Gene Name
Mouse CD54
Product Synonym Names
Intercellular adhesion molecule 1; Icam1; MALA-2; MyD10; CD54; Icam-1
Clonality
Monoclonal
Isotype
IgG2b, kappa
Clone Number
YN1/1.7.4
Host
Rat
Species Reactivity
Mouse
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Concentration
0.5 mg/mL (lot specific)
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
Matching Pairs
Antibody: CD54 (MBS2558142)
Isotype Control: IgG2b Clone #LTF-2 (MBS2557886)
3D Structure
ModBase 3D Structure for P13597
Conjugation
PE/Cyanine7
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD54 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD54 antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Other Notes

Small volumes of anti-CD54 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD54 purchase

MBS2558142 is an antibody targeting CD54. Also known as Anti-Mouse CD54 Monoclonal Antibody (PE/Cyanine7 Conjugated) [YN1/1.7.4]. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD54. It may not necessarily be applicable to this product.

NCBI GI #
124099
NCBI GeneID
15894
NCBI Accession #
P13597.1
UniProt Primary Accession #
P13597
UniProt Related Accession #
P13597
NCBI Official Full Name
Intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Official Symbol
Icam1
NCBI Official Synonym Symbols
CD54; Ly-47; Icam-1; MALA-2
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
MALA-2; MyD10; CD_antigen: CD54
Protein Family
Intercellular adhesion molecule
UniProt Gene Name
Icam1
UniProt Synonym Gene Names
Icam-1; ICAM-1
UniProt Entry Name
ICAM1_MOUSE
NCBI Protein Information
intercellular adhesion molecule 1

NCBI Summary for CD54

This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]

UniProt Comments for CD54

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily

Cellular Component: extracellular space; cell surface; focal adhesion; membrane; integral to plasma membrane; integral to membrane; plasma membrane; immunological synapse; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein complex binding

Biological Process: regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; cell-cell adhesion; leukocyte adhesion; positive regulation of peptidyl-tyrosine phosphorylation; sensory perception of sound; positive regulation of actin filament polymerization; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; cell adhesion; acute inflammatory response to antigenic stimulus
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Research Articles on CD54

1. these observations identify ICAM-1 as a novel regulator of Group 2 innate lymphoid cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD54 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD54 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5594 publications with CD54 and Inflammation
 Necrosis Antibodies  >4767 publications with CD54 and Necrosis
 Cardiovascular Diseases Antibodies  >3629 publications with CD54 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1453 publications with CD54 and Atherosclerosis
 Reperfusion Injury Antibodies  >880 publications with CD54 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >793 publications with CD54 and Myocardial Ischemia
 Kidney Diseases Antibodies  >758 publications with CD54 and Kidney Diseases
 Liver Diseases Antibodies  >549 publications with CD54 and Liver Diseases
 Hypertension Antibodies  >520 publications with CD54 and Hypertension
 Asthma Antibodies  >502 publications with CD54 and Asthma

Organs/Tissues associated with anti-CD54 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1767 publications with CD54 and Lung
 Skin Antibodies  >1195 publications with CD54 and Skin
 Liver Antibodies  >1177 publications with CD54 and Liver
 Kidney Antibodies  >1171 publications with CD54 and Kidney
 Brain Antibodies  >1171 publications with CD54 and Brain
 Embryonic Tissue Antibodies  >772 publications with CD54 and Embryonic Tissue
 Bone Antibodies  >665 publications with CD54 and Bone
 Intestine Antibodies  >538 publications with CD54 and Intestine
 Bone Marrow Antibodies  >480 publications with CD54 and Bone Marrow
 Lymph Node Antibodies  >408 publications with CD54 and Lymph Node
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