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Angiopoietin-Like Protein 3 (ANGPTL3) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691488

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert… More details

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Product Overview

Online Datasheet in PDF
Product Name
Angiopoietin-like protein 3 (ANGPTL3), Active Protein
Full Product Name
Human Angiopoietin-like protein 3
Product Gene Name
Product Synonym Names
ANGPTL-3; ANG-5; ANGPT5
Sequence
SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVH KTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL Q VKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQP ETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KE IENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPA EC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRI DGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIEL E DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLV FSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH
Host
CHO Cells
Species Reactivity
Human
Form/Format
Lyophilized
Molecular Weight
53,637 Da
Chromosome Location
Chromosome: 1; NC_000001.11 (62597487..62606305). Location: 1p31.3
OMIM
604774
3D Structure
ModBase 3D Structure for Q9Y5C1
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Label/Conjugation
His-Tag
Biological Activity
Measured by its binding ability to recombinant alphavbeta3 integrin in a functional ELISA.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of ANGPTL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANGPTL3 purchase

MBS691488 is an active protein targeting ANGPTL3. Also known as Human Angiopoietin-like protein 3. Reactive in Human. Host: CHO Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for ANGPTL3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
angiopoietin-related protein 3 preproprotein
NCBI Official Synonym Full Names
angiopoietin-like 3
NCBI Official Symbol
ANGPTL3
NCBI Official Synonym Symbols
ANL3; ANG-5; FHBL2; ANGPT5
UniProt Protein Name
Angiopoietin-related protein 3
UniProt Synonym Protein Names
Angiopoietin-5; ANG-5; Angiopoietin-like protein 3
UniProt Gene Name
ANGPTL3
UniProt Synonym Gene Names
ANGPT5; ANG-5
UniProt Entry Name
ANGL3_HUMAN
NCBI Protein Information
angiopoietin-related protein 3; angiopoietin 5

NCBI Summary for ANGPTL3

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
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UniProt Comments for ANGPTL3

Subunit structure: Interacts with C19orf80/ANGPTL8. Ref.9

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed principally in liver. Weakly expressed in kidney. Ref.1

Involvement in disease: Hypobetalipoproteinemia, familial, 2 (FHBL2) [MIM:605019]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Contains 1 fibrinogen C-terminal domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ANGPTL3 active protein

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