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FGF-18 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691570

FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and… More details

$305 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGF-18, Active Protein
Full Product Name
Human FGF-18
Product Gene Name
Product Synonym Names
Recombinant Human FGF-18
Sequence
AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRR ISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL V GKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGP KTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 95% by SDS-PAGE and HPLC analyses
Molecular Weight
21.2 kDa
Chromosome Location
Chromosome: 5; NC_000005.10 (171419663..171457626). Location: 5q34
OMIM
603726
3D Structure
ModBase 3D Structure for O76093
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per g of FGF-18
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is <= 0.5 ng/ml (>= 2 x 106 units/mg).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of FGF-18 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF-18 purchase

MBS691570 is an active protein targeting FGF-18. Also known as Human FGF-18. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF-18. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
fibroblast growth factor 18
NCBI Official Synonym Full Names
fibroblast growth factor 18
NCBI Official Symbol
FGF18
NCBI Official Synonym Symbols
ZFGF5; FGF-18
UniProt Protein Name
Fibroblast growth factor 18
UniProt Synonym Protein Names
zFGF5
UniProt Gene Name
FGF18
UniProt Synonym Gene Names
FGF-18
UniProt Entry Name
FGF18_HUMAN
NCBI Protein Information
fibroblast growth factor 18

NCBI Summary for FGF-18

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF-18

Function: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Ref.8

Subunit structure: Interacts with FGFR3 and FGFR4. Ref.8

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the heparin-binding growth factors family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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