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Prox-1 (Fragment) (PROX-1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691976

Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish… More details

$295 / 0.005 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Prox-1 (fragment), Recombinant Protein
Full Product Name
Human Prox-1 (fragment)
Product Synonym Names
Recombinant Human Prox-1; Homeobox prospero-like protein 1
Sequence
MAEGLSLSLI KSECGDLQDM SEISPYSGSA MQEGLSPNHL KKAKLMFFYT RYPSSNMLKT YFSDVKFNRC ITSQLIKWFS NFREFYYIQM EKYARQAIND GVTSTEELSI TRDCELYRAL NMHYNKANDF EVPERFLEVA QITLREFFNA IIAGKDVDPS WKKAIYKVIC KLDSEVPEIF KSPNCLQELL HE
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 95% by SDS-PAGE & silver stain
Preparation and Storage
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20 degree C. Reconstituted Prox-1 should be stored in working aliquots at -20 degree C. Avoid repeated freeze-thaw cycles.
Molecular Weight
22.35 kDa
Chromosome Location
Chromosome: 1; NC_000001.11 (213987935..214041510). Location: 1q41
OMIM
601546
3D Structure
ModBase 3D Structure for Q92786
Buffer
PBS
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Product References and Citations for Prox-1 recombinant protein

1. Belecky et al., Invest Ophthalmol Vis Sci 38, 1293 (1997) 2. Glasgow, Tomarev, Mech. Dev. 76, 175 (1998) 3. Rodriguez-Niedenfuhr et al., Anat Embryol 204, 399 (2001) 4. Wilting et al., FASEB J 16, 1271 (2002) 5. Krishnan et al., Cancer Res. 63, 713 (2003) 6. Mouta et al., Cancer Res. 61, 8079, (2001) 7.; Padera et al., Science 296, 1883 (2002)]

Other Notes

Small volumes of Prox-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Prox-1 purchase

MBS691976 is a recombinant protein targeting Prox-1. Also known as Human Prox-1 (fragment). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Prox-1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
prospero homeobox protein 1
NCBI Official Synonym Full Names
prospero homeobox 1
NCBI Official Symbol
PROX1
UniProt Protein Name
Prospero homeobox protein 1
UniProt Synonym Protein Names
Homeobox prospero-like protein PROX1
UniProt Gene Name
PROX1
UniProt Synonym Gene Names
PROX-1
UniProt Entry Name
PROX1_HUMAN
NCBI Protein Information
prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1

NCBI Summary for Prox-1

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
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UniProt Comments for Prox-1

Function: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons

By similarity.

Subcellular location: Nucleus

Probable.

Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

Sequence similarities: Belongs to the Prospero homeobox family.Contains 1 Prospero-type homeobox DNA-binding domain.

Sequence caution: The sequence CAI15309.1 differs from that shown. Reason: Erroneous gene model prediction.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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