Bovine SRY Recombinant Protein – Cat# MBS692130

SRY Bovine Recombinant Protein

Name: SRY Recombinant Protein; Bovine; MyBioSource
Brand: MyBioSource
SKU: MBS692130
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692130

The "žSex determining region of Y-Gen" (SRY), known as SRY gene, is coding for a transkription factor (TDF for Testis-determining factor). It belongs to the protein family of DNA binding-proteins. The SRY gene is beside other genes used for the… More details

$455 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SRY, Recombinant Protein

Full Product Name

Bovine SRY

Product Gene Name

SRY recombinant protein

Product Synonym Names

Recombinant Bovine SRY; Sex-determining region Y protein; Testis-determining factor

Sequence

N-Terminal Sequence: MFRVLN

Host

E Coli

Species Reactivity

Bovine

Form/Format

Lyophilized

Purity/Purification

> 90% by SDS-PAGE & silver stain

Preparation and Storage

The lyophilized powder although stable at room temperature for 3 weeks, is best stored desiccated at -20 degree C. Reconstituted bo SRY should be stored in working aliquots at -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA).

Molecular Weight

26,8 kDa

Chromosome Location

Chromosome: 13; AC_000170.1 (5424637..5425326, complement). Location: chromosome: Y

3D Structure

ModBase 3D Structure for Q03255

N Terminal Sequence

MFRVLN

Buffer

ddH2O

Product Categories/Family for SRY recombinant protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Product References and Citations for SRY recombinant protein

1. Harikae K et al, J Reprod Dev 2012; 58:654-60 2. Hamilton CK et al, Theriogenology 2012; 77:1587-96 3. Gou X et al, J Anim Breed Genet 2010; 127:154-60 4. Ross DG et al, BMC Mol Biol 2008; 9:85 5. Lu W et al, Anim Reprod Sci 2007; 100:186-91

Other Notes

Small volumes of SRY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRY purchase

MBS692130 is a recombinant protein targeting SRY. Also known as Bovine SRY. Reactive in Bovine. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SRY. It may not necessarily be applicable to this product.

NCBI GI #

62177084

NCBI GeneID

280931

NCBI Accession #

NP_001014407.1

UniProt Primary Accession #

Q03255

UniProt Secondary Accession #

A1XCJ6; A8WDV8

UniProt Related Accession #

Q03255

GenBank Nucleotide #

NM_001014385.1

NCBI Official Full Name

sex-determining region Y protein

NCBI Official Symbol

SRY

UniProt Protein Name

Sex-determining region Y protein

UniProt Synonym Protein Names

Testis-determining factor

Protein Family

Sex-determining region Y protein

UniProt Gene Name

SRY

UniProt Synonym Gene Names

TDF

UniProt Entry Name

SRY_BOVIN

NCBI Protein Information

sex-determining region Y protein; sex determining factor Y; testis-determining factor; sex-determining region of the Y-chromosome

UniProt Comments for SRY

Function: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'

By similarity.

Subunit structure: Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1

By similarity.

Subcellular location: Nucleus speckle

By similarity. Cytoplasm

By similarity.

Post-translational modification: Phosphorylation on serine residues enhances its DNA-binding activity and stimulates transcription repression. Acetylation of Lys-130 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Poly-ADP-ribosylation reduces its DNA-binding activity

By similarity.

Sequence similarities: Belongs to the SRY family.Contains 1 HMG box DNA-binding domain.

Research Articles on SRY

1. analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SRY recombinant protein

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram

Diseases associated with SRY recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>135 publications with SRY and Heart Diseases
Nervous System Diseases Antibodies	>78 publications with SRY and Nervous System Diseases
Kidney Diseases Antibodies	>37 publications with SRY and Kidney Diseases
46,XY SEX REVERSAL 1 Antibodies	>35 publications with SRY and 46,XY SEX REVERSAL 1
Hyperplasia Antibodies	>32 publications with SRY and Hyperplasia
Liver Diseases Antibodies	>27 publications with SRY and Liver Diseases
Adenocarcinoma Antibodies	>27 publications with SRY and Adenocarcinoma
46,XX SEX REVERSAL 1 Antibodies	>26 publications with SRY and 46,XX SEX REVERSAL 1
Necrosis Antibodies	>23 publications with SRY and Necrosis
Hypertrophy Antibodies	>19 publications with SRY and Hypertrophy