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MIP-1beta Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695065

Produced from sera of rabbits pre-immunized with highly pure recombinant Murine MIP-1beta. Anti-Murine MIP-1beta specific antibody was purified by affinity chromatography employing immobilized Murine MIP-1beta matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MIP-1beta, Polyclonal Antibody
Full Product Name
Anti-murine MIP-1beta
Product Gene Name
anti-MIP-1beta antibody
Product Synonym Names
Anti-Murine MIP-1beta
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
10,168 Da
3D Structure
ModBase 3D Structure for P14097
Immunogen
Recombinant Murine MIP-1beta
Applications Tested/Suitable for anti-MIP-1beta antibody
Neutralization, ELISA (EIA), Western Blot (WB)
Application Notes for anti-MIP-1beta antibody
Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Murine MIP-1beta (100.0 ng/ml), a concentration of 8.0-10.0 mug/ml of this antibody is required.

Sandwich ELISA: To detect Murine MIP-1beta by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine MIP-1beta as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Murine MIP-1beta.

Western Blot: To detect Murine MIP-1beta by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Murine MIP-1beta is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-MIP-1beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1beta purchase

MBS695065 is an antibody targeting MIP-1beta. Also known as Anti-murine MIP-1beta. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1beta. It may not necessarily be applicable to this product.

NCBI GI #
1346534
NCBI GeneID
20303
NCBI Accession #
P14097.3
UniProt Primary Accession #
P14097
UniProt Related Accession #
P14097
NCBI Official Full Name
C-C motif chemokine 4
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 4
NCBI Official Symbol
Ccl4
NCBI Official Synonym Symbols
Act-2; Mip1b; Scya4; MIP-1B; AT744.1
UniProt Protein Name
C-C motif chemokine 4
UniProt Synonym Protein Names
Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4
UniProt Gene Name
Ccl4
UniProt Synonym Gene Names
Mip1b; Scya4; ACT-2; ACT2; MIP-1-beta
UniProt Entry Name
CCL4_MOUSE
NCBI Protein Information
C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1 beta; MIP-1-beta; immune activation protein 2; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta

UniProt Comments for MIP-1beta

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: response to toxin; leukocyte chemotaxis; positive regulation of calcium-mediated signaling; immune response; inflammatory response; positive regulation of tumor necrosis factor production; chemotaxis; positive regulation of calcium ion transport; positive regulation of vascular permeability
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Research Articles on MIP-1beta

1. CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIP-1beta antibody

 Reference Product  PubMed Publications
 Ccl3 antibody  >1605 publications with MIP-1beta and Ccl3
 Ccl5 antibody  >990 publications with MIP-1beta and Ccl5
 Ccr5 antibody  >590 publications with MIP-1beta and Ccr5
 Ccr1 antibody  >197 publications with MIP-1beta and Ccr1
 Ccr2 antibody  >108 publications with MIP-1beta and Ccr2
 Cxcr3 antibody  >75 publications with MIP-1beta and Cxcr3
 Ccl7 antibody  >74 publications with MIP-1beta and Ccl7
 Ccr3 antibody  >71 publications with MIP-1beta and Ccr3
 Ccr8 antibody  >24 publications with MIP-1beta and Ccr8
 Ccl12 antibody  >12 publications with MIP-1beta and Ccl12

Pathways associated with anti-MIP-1beta antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-MIP-1beta antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2606 publications with MIP-1beta and Liver Diseases
 Poisoning Antibodies  >1973 publications with MIP-1beta and Poisoning
 Drug-Induced Liver Injury Antibodies  >1578 publications with MIP-1beta and Drug-Induced Liver Injury
 Disease Models, Animal Antibodies  >1268 publications with MIP-1beta and Disease Models, Animal
 Necrosis Antibodies  >1201 publications with MIP-1beta and Necrosis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1169 publications with MIP-1beta and Drug-Related Side Effects and Adverse Reactions
 Liver Cirrhosis Antibodies  >1136 publications with MIP-1beta and Liver Cirrhosis
 Inflammation Antibodies  >1080 publications with MIP-1beta and Inflammation
 Fibrosis Antibodies  >928 publications with MIP-1beta and Fibrosis
 Fatty Liver Antibodies  >287 publications with MIP-1beta and Fatty Liver

Organs/Tissues associated with anti-MIP-1beta antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >296 publications with MIP-1beta and Bone Marrow
 Spleen Antibodies  >219 publications with MIP-1beta and Spleen
 Skin Antibodies  >137 publications with MIP-1beta and Skin
 Eye Antibodies  >61 publications with MIP-1beta and Eye
 Uncharacterized Tissue Antibodies  >1 publications with MIP-1beta and Uncharacterized Tissue
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