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IMPDH2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9125036
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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IMPDH2, Polyclonal Antibody
Full Product Name
IMPDH2 Polyclonal Antibody
Product Gene Name
anti-IMPDH2 antibody
Product Synonym Names
IMPD2; IMPDH-II
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
514
OMIM
146691
3D Structure
ModBase 3D Structure for P12268
Species
Human
Immunogen
Recombinant protein of human IMPDH2
Calculated Molecular Weight
55kDa

Product Categories/Family for anti-IMPDH2 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IMPDH2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-IMPDH2 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Western Blot (WB) of anti-IMPDH2 antibody

Western blot analysis of extracts of various cell lines, using IMPDH2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 20s.
Rabbit Anti-IMPDH2 Polyclonal Antibody – Cat# MBS9125036

Immunofluorescence (IF) of anti-IMPDH2 antibody

Immunofluorescence analysis of HeLa cells using IMPDH2 antibody.
Rabbit Anti-IMPDH2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9125036

Other Notes

Small volumes of anti-IMPDH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMPDH2 purchase

MBS9125036 is an antibody targeting IMPDH2. Also known as IMPDH2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.

NCBI GI #
124419
NCBI GeneID
3615
NCBI Accession #
P12268.2
UniProt Primary Accession #
P12268
UniProt Secondary Accession #
Q6LEF3
UniProt Related Accession #
P12268
NCBI Official Full Name
Inosine-5'-monophosphate dehydrogenase 2
NCBI Official Synonym Full Names
IMP (inosine 5'-monophosphate) dehydrogenase 2
NCBI Official Symbol
IMPDH2
NCBI Official Synonym Symbols
IMPD2; IMPDH-II
UniProt Protein Name
Inosine-5'-monophosphate dehydrogenase 2
UniProt Synonym Protein Names
IMPDH-II
UniProt Gene Name
IMPDH2
UniProt Entry Name
IMDH2_HUMAN
NCBI Protein Information
inosine-5'-monophosphate dehydrogenase 2; IMPD 2; IMPDH2; IMPDH 2; IMP oxireductase 2; inosine 5' phosphate dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; inosine monophosphate dehydrogenase type II

UniProt Comments for IMPDH2

IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: peroxisomal membrane; membrane; cytoplasm; nucleus; cytosol

Molecular Function: DNA binding; RNA binding; metal ion binding; nucleotide binding; IMP dehydrogenase activity

Biological Process: purine ribonucleoside monophosphate biosynthetic process; lymphocyte proliferation; retina development in camera-type eye; nucleobase, nucleoside and nucleotide metabolic process; GMP biosynthetic process; purine base metabolic process; protein homotetramerization
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Research Articles on IMPDH2

1. Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IMPDH2 antibody

 Reference Product  PubMed Publications
 HPRT1 antibody  >3 publications with IMPDH2 and HPRT1
 ITPA antibody  >2 publications with IMPDH2 and ITPA
 GMPR2 antibody  >1 publications with IMPDH2 and GMPR2
 GMPS antibody  >1 publications with IMPDH2 and GMPS

Pathways associated with anti-IMPDH2 antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-IMPDH2 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with IMPDH2 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with IMPDH2 and Kidney Diseases
 Leukemia Antibodies  >4 publications with IMPDH2 and Leukemia
 Inflammation Antibodies  >3 publications with IMPDH2 and Inflammation
 Diarrhea Antibodies  >3 publications with IMPDH2 and Diarrhea
 Neoplasms, Experimental Antibodies  >2 publications with IMPDH2 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >2 publications with IMPDH2 and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >2 publications with IMPDH2 and Prostatic Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with IMPDH2 and Uterine Cervical Neoplasms
 Anemia Antibodies  >1 publications with IMPDH2 and Anemia

Organs/Tissues associated with anti-IMPDH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with IMPDH2 and Blood
 Kidney Antibodies  >18 publications with IMPDH2 and Kidney
 Liver Antibodies  >4 publications with IMPDH2 and Liver
 Prostate Antibodies  >4 publications with IMPDH2 and Prostate
 Bone Antibodies  >4 publications with IMPDH2 and Bone
 Pancreas Antibodies  >2 publications with IMPDH2 and Pancreas
 Heart Antibodies  >2 publications with IMPDH2 and Heart
 Eye Antibodies  >2 publications with IMPDH2 and Eye
 Testis Antibodies  >1 publications with IMPDH2 and Testis
 Uterus Antibodies  >1 publications with IMPDH2 and Uterus
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