Rabbit Anti-IP-10 Polyclonal Antibody – Cat# MBS695346

IP-10 Antibody – Rabbit Polyclonal

Name: IP-10 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695346
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695346

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant mIP-10. Anti-Murine IP-10 specific antibody was purified by affinity chromatography employing immobilized mIP-10 matrix. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IP-10, Polyclonal Antibody

Full Product Name

Anti-murine IP-10

Product Gene Name

anti-IP-10 antibody

Product Synonym Names

Anti-Murine IP-10

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Purified

Preparation and Storage

At -20 degree C

Molecular Weight

10,789 Da

3D Structure

ModBase 3D Structure for P17515

Immunogen

Recombinant Murine IP-10

Applications Tested/Suitable for anti-IP-10 antibody

Immunohistochemistery (IHC), Neutralization, ELISA (EIA), Western Blot (WB)

Application Notes for anti-IP-10 antibody

Immunohistochemistery: This antibody stained colchicine injected mouse brain (including the hippocampus region) tissue. The primary antibody was incubated at 1.0 mg/ml overnight at 4 degree C. This was followed by a peroxidase conjugated secondary antibody and then a fluorescein Tyramide Signal Amplification (TSA™) reagent.

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of mIP-10 (100.0 ng/ml), a concentration of 10.0 ug/ml of this antibody is required.

Sandwich ELISA: To detect mIP-10 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IP-10 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIP-10.

Western Blot: To detect mIP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant mIP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP-10 purchase

MBS695346 is an antibody targeting IP-10. Also known as Anti-murine IP-10. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #

124494

NCBI GeneID

15945

NCBI Accession #

P17515.1

UniProt Primary Accession #

P17515

UniProt Related Accession #

P17515

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

Cxcl10

NCBI Official Synonym Symbols

C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10

UniProt Gene Name

Cxcl10

UniProt Synonym Gene Names

Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_MOUSE

NCBI Protein Information

C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10

UniProt Comments for IP-10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of myoblast differentiation; inflammatory response; defense response to virus; positive regulation of cell migration

Research Articles on IP-10

1. data indicate that epithelium-expressed CXCL10 plays a critical role in fungal clearance and that CXCR3-expressing NK cells contribute to CA eradication in mouse corneas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IP-10 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP-10 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1119 publications with IP-10 and Inflammation
Necrosis Antibodies	>650 publications with IP-10 and Necrosis
Lung Diseases Antibodies	>319 publications with IP-10 and Lung Diseases
Liver Diseases Antibodies	>220 publications with IP-10 and Liver Diseases
Cardiovascular Diseases Antibodies	>161 publications with IP-10 and Cardiovascular Diseases
Fibrosis Antibodies	>123 publications with IP-10 and Fibrosis
Neoplasms, Experimental Antibodies	>110 publications with IP-10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>83 publications with IP-10 and Kidney Diseases
Lung Injury Antibodies	>61 publications with IP-10 and Lung Injury
Pneumonia Antibodies	>59 publications with IP-10 and Pneumonia

Organs/Tissues associated with anti-IP-10 antibody

Organ/Tissue Name	Pubmed Publications
Lymph Node Antibodies	>155 publications with IP-10 and Lymph Node
Spleen Antibodies	>127 publications with IP-10 and Spleen
Bone Marrow Antibodies	>121 publications with IP-10 and Bone Marrow
Eye Antibodies	>90 publications with IP-10 and Eye
Intestine Antibodies	>87 publications with IP-10 and Intestine
Embryonic Tissue Antibodies	>52 publications with IP-10 and Embryonic Tissue
Thymus Antibodies	>52 publications with IP-10 and Thymus
Mammary Gland Antibodies	>8 publications with IP-10 and Mammary Gland
Epididymis Antibodies	>1 publications with IP-10 and Epididymis