Human ApoE Recombinant Protein – Cat# MBS286103

Apolipoprotein E (ApoE) Human Recombinant Protein

Name: ApoE Recombinant Protein; Apolipoprotein E; Human; MyBioSource
Brand: MyBioSource
SKU: MBS286103
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS286103

Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Apolipoprotein E has many functions in the… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Apolipoprotein E (ApoE), Recombinant Protein

Full Product Name

Recombinant Human Apolipoprotein E (ApoE) Protein

Product Gene Name

ApoE recombinant protein

Product Synonym Names

Apo-E; APOE; ApoE

Sequence

MKVLWAALLV TFLAGCQAKV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT LSEQVQEELL SSQ VTQELRALMD ETMKELKAYK SELEEQLTPV AEETRARLSK ELQAAQARLG ADMEDVCGRL VQYRGEVQAM LGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQ ERAQAWGERL RARMEEMGSR TRDRLDEVKE QVAEVRAKLE EQAQQIRLQA EAFQARLKSW FEPLVEDMQR QW AGLVEKVQAA VGTSAAPVPS DNH

Host

Mammalian Cells 1-317 AA (P02649).

Form/Format

Supplied in 20 mM PB, 150 mM NaCl, pH 7.4.

Purity/Purification

> 90 % as determined by SDS-PAGE.

Concentration

0.5 mg/mL (lot specific)

Preparation and Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. The recombinant protein is stable for up to 12 months from date of receipt at -80°C. **Avoid repeated freeze-thaw cycles.**

Molecular Weight

Observed MW: 50 kDa

OMIM

M12529 mRNA

3D Structure

ModBase 3D Structure for P02649

Source

Human

Protein Residues

C-terminal 6X His-tagged.

Usage

ApoE Protein - Centrifuge the standard vial at 6000-10000rpm for 30s.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for ApoE recombinant protein

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of ApoE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ApoE purchase

MBS286103 is a recombinant protein targeting ApoE. Also known as Recombinant Human Apolipoprotein E (ApoE) Protein. Host: Mammalian Cells 1-317 AA (P02649).

Additional Details

NCBI/Uniprot data below describe general gene information for ApoE. It may not necessarily be applicable to this product.

NCBI GI #

4557325

NCBI GeneID

348

NCBI Accession #

NP_000032.1

UniProt Primary Accession #

P02649

UniProt Secondary Accession #

Q9P2S4; B2RC15; C0JYY5

UniProt Related Accession #

P02649

GenBank Nucleotide #

NM_000041.3

NCBI Official Full Name

apolipoprotein E isoform b

NCBI Official Synonym Full Names

apolipoprotein E

NCBI Official Symbol

APOE

NCBI Official Synonym Symbols

AD2; LPG; APO-E; ApoE4; LDLCQ5

UniProt Protein Name

Apolipoprotein E

Protein Family

Apolipoprotein

UniProt Gene Name

APOE

UniProt Synonym Gene Names

Apo-E

UniProt Entry Name

APOE_HUMAN

NCBI Protein Information

apolipoprotein E

NCBI Summary for ApoE

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

UniProt Comments for ApoE

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Research Articles on ApoE

1. APOE4 is significantly associated with dementia and Cognitive Impairment due to Alzheimer's Disease pathology, but not with Vascular Cognitive impairment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ApoE recombinant protein

Reference Product	PubMed Publications
APOB recombinant protein	>1561 publications with ApoE and APOB
LDLR recombinant protein	>643 publications with ApoE and LDLR
LPL recombinant protein	>343 publications with ApoE and LPL
APOA1 recombinant protein	>173 publications with ApoE and APOA1
LRP1 recombinant protein	>93 publications with ApoE and LRP1
APOC3 recombinant protein	>88 publications with ApoE and APOC3
APOA2 recombinant protein	>23 publications with ApoE and APOA2
LRP8 recombinant protein	>17 publications with ApoE and LRP8
HSPG2 recombinant protein	>7 publications with ApoE and HSPG2
LRP2 recombinant protein	>5 publications with ApoE and LRP2

Pathways associated with ApoE recombinant protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway antibodies	Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Chylomicron-mediated Lipid Transport Pathway antibodies	Chylomicron-mediated Lipid Transport Pathway Diagram
Composition Of Lipid Particles Pathway antibodies	Composition Of Lipid Particles Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
HDL-mediated Lipid Transport Pathway antibodies	HDL-mediated Lipid Transport Pathway Diagram

Diseases associated with ApoE recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>6965 publications with ApoE and Cardiovascular Diseases
Alzheimer Disease Antibodies	>6313 publications with ApoE and Alzheimer Disease
Atherosclerosis Antibodies	>5656 publications with ApoE and Atherosclerosis
Arteriosclerosis Antibodies	>4587 publications with ApoE and Arteriosclerosis
Dyslipidemias Antibodies	>2178 publications with ApoE and Dyslipidemias
Inflammation Antibodies	>2095 publications with ApoE and Inflammation
Hyperlipidemias Antibodies	>1934 publications with ApoE and Hyperlipidemias
Cognition Disorders Antibodies	>1661 publications with ApoE and Cognition Disorders
Plaque, Atherosclerotic Antibodies	>1609 publications with ApoE and Plaque, Atherosclerotic
Coronary Disease Antibodies	>1252 publications with ApoE and Coronary Disease

Organs/Tissues associated with ApoE recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5075 publications with ApoE and Brain
Vascular Antibodies	>4813 publications with ApoE and Vascular
Liver Antibodies	>2078 publications with ApoE and Liver
Heart Antibodies	>1856 publications with ApoE and Heart
Muscle Antibodies	>1354 publications with ApoE and Muscle
Nerve Antibodies	>693 publications with ApoE and Nerve
Bone Antibodies	>675 publications with ApoE and Bone
Kidney Antibodies	>572 publications with ApoE and Kidney
Lung Antibodies	>338 publications with ApoE and Lung
Spleen Antibodies	>280 publications with ApoE and Spleen