Human sCD100 Active Protein – Cat# MBS696000

Scd100 / Semaphorin-4d (sCD100) Human Active Protein

Name: sCD100 Active Protein; Scd100 / Semaphorin-4d; Human; MyBioSource
Brand: MyBioSource
SKU: MBS696000
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696000

The Semphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Twenty members of this family have been identified and categorized into eight subclasses based on sequence… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

sCD100 / Semaphorin-4D, Active Protein

Full Product Name

Human sCD100 / Semaphorin-4D

Product Gene Name

sCD100 active protein

Product Synonym Names

Recombinant Human sCD100

Sequence

FAPIPRITW EHREVHLVQ FHEPDIYNY SALLLSEDK DTLYIGARE AVFAVNALN ISEKQHEVY WKVSEDKKA KCAEKGKSK QTECLNYIR VLQPLSATS LYVCGTNAF QPACDHLNL TSFKFLGKN EDGKGRCPF DPAHSYTSV MVDGELYSG TSYNFLGSE PIISRNSSH SPLRTEYAI PWLNEPSFV FADVIRKSP DSPDGEDDR VYFFFTEVS VEYEFVFRV LIPRIARVC KGDQGGLRT LQKKWTSFL KARLICSRP DSGLVFNVL RDVFVLRSP GLKVPVFYA LFTPQLNNV GLSAVCAYN LSTAEEVFS HGKYMQSTT VEQSHTKWV RYNGPVPKP RPGACIDSE ARAANYTSS LNLPDKTLQ FVKDHPLMD DSVTPIDNR PRLIKKDVN YTQIVVDRT QALDGTVYD VMFVSTDRG ALHKAISLE HAVHIIEET QLFQDFEPV QTLLLSSKK GNRFVYAGS NSGVVQAPL AFCGKHGTC EDCVLARDP YCAWSPPTA TCVALHQTE SPSRGLIQE MSGDASVCP DKSKGSYRQ HFFKHGGTA ELKCSQKSN LARVFWKFQ NGVLKAESP KYGLMGRKN LLIFNLSEG DSGVYQCLS EERVKNKTV FQVVAKHVL EVKVVPKPV VAPTLSVVQ TEGSRIATK VLVASTQGS SPPTPAVQA TSSGAITLP PKPAPTGTS CEPKIVINT VPQLHSEKT MYLKSSDNR

Host

CHO cells

Species Reactivity

Species Reactivity: Human

Purity/Purification

Above 97% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

82,164 Da

OMIM

601866

3D Structure

ModBase 3D Structure for Q92854

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured by its ability to inhibit chemokine (hMCP-3) induced human monocyte migration.

Cell Type

B Cells, Monocytes and Macrophages, T Cells

Product Categories/Family for sCD100 active protein

Innate Immunity; Adaptive Immunity; Chemotaxis

Other Notes

Small volumes of sCD100 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for sCD100 purchase

MBS696000 is an active protein targeting sCD100. Also known as Human sCD100 / Semaphorin-4D. Reactive in Species Reactivity: Human. Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for sCD100. It may not necessarily be applicable to this product.

NCBI GI #

8134701

NCBI GeneID

10507

NCBI Accession #

Q92854.1

UniProt Primary Accession #

Q92854

UniProt Secondary Accession #

Q7Z5S4; Q8N8B0; B2RPM6

UniProt Related Accession #

Q92854

NCBI Official Full Name

Semaphorin-4D

NCBI Official Synonym Full Names

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

NCBI Official Symbol

SEMA4D

NCBI Official Synonym Symbols

CD100; SEMAJ; coll-4; C9orf164; M-sema-G

UniProt Protein Name

Semaphorin-4D

UniProt Synonym Protein Names

A8; BB18; GR3; CD_antigen: CD100

UniProt Gene Name

SEMA4D

UniProt Synonym Gene Names

C9orf164; CD100; SEMAJ

UniProt Entry Name

SEM4D_HUMAN

NCBI Protein Information

semaphorin-4D; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D

UniProt Comments for sCD100

SEMA4D: a single-pass type I membrane protein that my play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability in vitro.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor activity; semaphorin receptor binding; receptor binding

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; axon guidance; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell adhesion; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of osteoblast differentiation; immune response; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of collateral sprouting; regulation of cell projection organization and biogenesis; positive regulation of cell migration; negative regulation of apoptosis

Research Articles on sCD100

1. results suggest that the contribution of Sema4D in platelets applies to ITAM-containing receptors as a class

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with sCD100 active protein

Reference Product	PubMed Publications
PLXNB1 active protein	>65 publications with sCD100 and PLXNB1
CD72 active protein	>36 publications with sCD100 and CD72
MET active protein	>18 publications with sCD100 and MET
ERBB2 active protein	>6 publications with sCD100 and ERBB2
PTPRC active protein	>5 publications with sCD100 and PTPRC
RND1 active protein	>4 publications with sCD100 and RND1
RRAS active protein	>3 publications with sCD100 and RRAS
ARHGEF12 active protein	>2 publications with sCD100 and ARHGEF12
ARHGEF11 active protein	>2 publications with sCD100 and ARHGEF11
GRLF1 active protein	>1 publications with sCD100 and GRLF1

Pathways associated with sCD100 active protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Other Semaphorin Interactions Pathway antibodies	Other Semaphorin Interactions Pathway Diagram
Sema4D In Semaphorin Signaling Pathway antibodies	Sema4D In Semaphorin Signaling Pathway Diagram
Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies	Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway antibodies	Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with sCD100 active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>23 publications with sCD100 and Nervous System Diseases
Brain Diseases Antibodies	>14 publications with sCD100 and Brain Diseases
Neovascularization, Pathologic Antibodies	>14 publications with sCD100 and Neovascularization, Pathologic
Inflammation Antibodies	>11 publications with sCD100 and Inflammation
Disease Models, Animal Antibodies	>9 publications with sCD100 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>9 publications with sCD100 and Cardiovascular Diseases
Kidney Diseases Antibodies	>4 publications with sCD100 and Kidney Diseases
Atherosclerosis Antibodies	>3 publications with sCD100 and Atherosclerosis
Necrosis Antibodies	>3 publications with sCD100 and Necrosis
Death Antibodies	>2 publications with sCD100 and Death

Organs/Tissues associated with sCD100 active protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>94 publications with sCD100 and Nerve
Blood Antibodies	>78 publications with sCD100 and Blood
Brain Antibodies	>30 publications with sCD100 and Brain
Embryonic Tissue Antibodies	>17 publications with sCD100 and Embryonic Tissue
Skin Antibodies	>8 publications with sCD100 and Skin
Spinal Cord Antibodies	>7 publications with sCD100 and Spinal Cord
Kidney Antibodies	>7 publications with sCD100 and Kidney
Lymph Node Antibodies	>7 publications with sCD100 and Lymph Node
Lung Antibodies	>6 publications with sCD100 and Lung
Liver Antibodies	>5 publications with sCD100 and Liver