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GDNF Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696024

GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a… More details

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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDNF, Active Protein
Full Product Name
Rat GDNF
Product Gene Name
GDNF active protein
Product Synonym Names
Recombinant Rat GDNF
Sequence
MSPDKQAAA LPRRERNRQ AAAASPENS RGKGRRGQR GKNRGCVLT AIHLNVTDL GLGYETKEE LIFRYCSGS CEAAETMYD KILKNLSRS RRLTSDKVG QACCRPVAF DDDLSFLDD SLVYHILRK HSAKRCGCI
Host
E Coli
Species Reactivity
Species Reactivity: Rat
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
23,551 Da
3D Structure
ModBase 3D Structure for Q07731
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells.
Cell Type
Stem Cells, Neurons

Product Categories/Family for GDNF active protein

Stem Cell Research; Angiogenesis; Neurosciences

Other Notes

Small volumes of GDNF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDNF purchase

MBS696024 is an active protein targeting GDNF. Also known as Rat GDNF. Reactive in Species Reactivity: Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDNF. It may not necessarily be applicable to this product.

NCBI GI #
729568
NCBI GeneID
25453
NCBI Accession #
Q07731.1
UniProt Primary Accession #
Q07731
UniProt Secondary Accession #
Q63214; Q64062; Q64063; Q8R485; Q9QX94; Q9QX95; Q9QXJ7; Q9QXJ8; Q9QXJ9
UniProt Related Accession #
Q07731
NCBI Official Full Name
Glial cell line-derived neurotrophic factor
NCBI Official Synonym Full Names
glial cell derived neurotrophic factor
NCBI Official Symbol
Gdnf
NCBI Official Synonym Symbols
gndf
UniProt Protein Name
Glial cell line-derived neurotrophic factor
UniProt Synonym Protein Names
Astrocyte-derived trophic factor; ATF
Protein Family
Glial cell line-derived neurotrophic factor
UniProt Gene Name
Gdnf
UniProt Synonym Gene Names
ATF
UniProt Entry Name
GDNF_RAT
NCBI Protein Information
glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor; Glial cell line derived neutrophic factor; glial cell line derived neurotrophic factor

NCBI Summary for GDNF

neurotrophic factor specific for midbrain dopamine neurons; binds to GDNFR-alpha and mediates activation of the Ret protein tyrosine kinase receptor [RGD, Feb 2006]

UniProt Comments for GDNF

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.

Research Articles on GDNF

1. ProGDNF is a biologically active protein with specific effects on the cells close to its secreting site and in the glia-neuronal interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GDNF active protein

 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with GDNF active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1369 publications with GDNF and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >610 publications with GDNF and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >561 publications with GDNF and Disease Models, Animal
 Movement Disorders Antibodies  >552 publications with GDNF and Movement Disorders
 Parkinsonian Disorders Antibodies  >516 publications with GDNF and Parkinsonian Disorders
 Parkinson Disease Antibodies  >453 publications with GDNF and Parkinson Disease
 Nerve Degeneration Antibodies  >279 publications with GDNF and Nerve Degeneration
 Neurologic Manifestations Antibodies  >191 publications with GDNF and Neurologic Manifestations
 Inflammation Antibodies  >163 publications with GDNF and Inflammation
 Brain Injuries Antibodies  >151 publications with GDNF and Brain Injuries

Organs/Tissues associated with GDNF active protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >168 publications with GDNF and Testis
 Uncharacterized Tissue Antibodies  >1 publications with GDNF and Uncharacterized Tissue
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