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GASP-1 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696145

Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-beta binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a… More details

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Product Overview

Product Name
GASP-1, Active Protein
Full Product Name
Human GASP-1
Product Gene Name
Product Synonym Names
Recombinant Human GASP-1
Sequence
LPPIRYSHA GICPNDMNP NLWVDAQST CRRECETDQ ECETYEKCC PNVCGTKSC VAARYMDVK GKKGPVGMP KEATCDHFM CLQQGSECD IWDGQPVCK CKDRCEKEP SFTCASDGL TYYNRCYMD AEACSKGIT LAVVTCRYH FTWPNTSPP PPETTMHPT TASPETPEL DMAAPALLN NPVHQSVTM GETVSFLCD VVGRPRPEI TWEKQLEDR ENVVMRPNH VRGNVVVTN IAQLVIYNA QLQDAGIYT CTARNVAGV LRADFPLSV VRGHQAAAT SESSPNGTA FPAAECLKP PDSEDCGEE QTRWHFDAQ ANNCLTFTF GHCHRNLNH FETYEACML ACMSGPLAA CSLPALQGP CKAYAPRWA YNSQTGQCQ SFVYGGCEG NGNNFESRE ACEESCPFP RGNQRCRAC KPRQKLVTS FCRSDFVIL GRVSELTEE PDSGRALVT VDEVLKDEK MGLKFLGQE PLEVTLLHV DWACPCPNV TVSEMPLII MGEVDGGMA MLRPDSFVG ASSARRVRK LREVMHKKT CDVLKEFLG LH
Host
CHO cells
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 95% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
63,941 Da
OMIM
610895
3D Structure
ModBase 3D Structure for Q8TEU8
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to inhibit human Myostatin (GDF-8) activity in MCP-11 cells. The ED50 for this effect is 0.0025-0.0040 ug/ml in the presence of 5ng/ml of human Myostatin (GDF-8).

Other Notes

Small volumes of GASP-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GASP-1 purchase

MBS696145 is an active protein targeting GASP-1. Also known as Human GASP-1. Reactive in Species Reactivity: Human. Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GASP-1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
NCBI Official Synonym Full Names
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
NCBI Official Symbol
WFIKKN2
NCBI Official Synonym Symbols
GASP-1; WFDC20B; hGASP-1; WFIKKNRP
UniProt Protein Name
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
UniProt Synonym Protein Names
Growth and differentiation factor-associated serum protein 1; GASP-1; hGASP-1; WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein; WFIKKN-related protein
UniProt Gene Name
WFIKKN2
UniProt Synonym Gene Names
GASP1; WFIKKNRP; GASP-1; hGASP-1
UniProt Entry Name
WFKN2_HUMAN
NCBI Protein Information
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; WFIKKN-related protein; WAP four-disulfide core domain 20B; multivalent protease inhibitor protein; WAP, FS, Ig, two KU and NTR module related protein; growth and differentiation factor-associated serum protein 1; WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein

NCBI Summary for GASP-1

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
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UniProt Comments for GASP-1

WFIKKN2: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin. Belongs to the WFIKKN family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity

Biological Process: transforming growth factor beta receptor signaling pathway; palate development; muscle fiber development; negative regulation of protein binding; skeletal development; negative regulation of DNA binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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