TGF-Beta3 (TGFB3) ELISA Kit for Human

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cell soma; cell surface; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bound organelle; nucleus; plasma membrane; T-tubule

Molecular Function: cytokine activity; growth factor activity; identical protein binding; protein binding; protein heterodimerization activity; transforming growth factor beta binding; type II transforming growth factor beta receptor binding

Biological Process: activation of MAPK activity; aging; alveolus development; BMP signaling pathway; cell development; cell growth; cell-cell junction organization; embryonic neurocranium morphogenesis; female pregnancy; gut development; in utero embryonic development; inner ear development; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; odontogenesis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of cell division; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of MAPK cascade; response to estrogen; response to hypoxia; response to progesterone; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; wound healing

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome