CD282 Antibody – Mouse Monoclonal

The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on peripheral blood monocytes and is involved distinguishing bacterial lipoproteins. The TL2.1 antibody blocks the receptor and immunoprecipitates TLR2 from human mammary epithelial cells (HMEC) and peripheral blood mononuclear cells (PBMC).

Flo, T. H., Halaas, Ø., Lien, E., Ryan, L., Teti, G., Golenbock, D. T.,... & Espevik, T. (2000). Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.The Journal of Immunology, 164(4), 2064-2069.
Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W.,... & Golenbock, D. T. (1999). Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry, 274(47), 33419-33425.
Cook, E. B., Stahl, J. L., Esnault, S., Barney, N. P., & Graziano, F. M. (2005). Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for< i> Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Annals of Allergy, Asthma & Immunology, 94(4), 486-497.

Small volumes of anti-CD282 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697060 is an antibody targeting CD282. Also known as Anti-Human CD282 (TLR2) FITC. Reactive in Human. Host: Mouse.