Selenoprotein S (VIMP) Antibody – Rabbit Polyclonal

This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

SELS: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. Belongs to the selenoprotein S family.

Protein type: Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: endoplasmic reticulum; cytoplasmic microtubule; plasma membrane; integral to endoplasmic reticulum membrane

Molecular Function: antioxidant activity; selenium binding; protein binding; enzyme binding; receptor activity

Biological Process: ER-associated protein catabolic process; unfolded protein response; negative regulation of acute inflammatory response to antigenic stimulus; response to redox state; negative regulation of tumor necrosis factor production; retrograde protein transport, ER to cytosol; negative regulation of glucose import; establishment of protein localization; cellular response to insulin stimulus; cell redox homeostasis; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of inflammatory response; response to glucose stimulus; negative regulation of interleukin-6 production; regulation of gluconeogenesis; ER overload response; negative regulation of glycogen biosynthetic process