Nude Nuclear Distribution Gene E Homolog 1 (A. Nidulans) (NDE1) Antibody – Rabbit Polyclonal

This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

NUDE1: a microtubule-associated protein required for centrosome duplication, and the formation and function of the mitotic spindle. Associated with the centrosome, kinetochore, and spindle. Specifically phosphorylated during M phase, inducing its association with mitotic spindles. Appears to participate in dynein-mediated transport of kinetochore proteins to spindle poles along microtubules. Interacts with gamma tubulin, dynactin, CEP110, dynein,TCP1. PAFAH1B1, PCM-1 and PCNT. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase, and at the cleavage furrow during cytokinesis.Two alternatively spliced human isoforms have been described.

Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding

Chromosomal Location of Human Ortholog: 16p13.11

Cellular Component: kinetochore; microtubule; kinesin complex; centrosome; membrane; spindle pole centrosome; cytosol; cleavage furrow

Molecular Function: protein domain specific binding; identical protein binding; protein binding; microtubule binding

Biological Process: cell migration; organelle organization and biogenesis; neuron migration; establishment of chromosome localization; microtubule nucleation; chromosome segregation; mitotic centrosome separation; establishment of mitotic spindle orientation; centrosome localization; cell division; neuroblast proliferation; vesicle transport along microtubule; cerebral cortex development; mitotic cell cycle; G2/M transition of mitotic cell cycle; centrosome duplication

Disease: Lissencephaly 4; Microhydranencephaly