Heat Shock 70kDa Protein 2 (HSPA2) Antibody – Rabbit Polyclonal

HSPA2: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Interacts with ZNF541. Component of the CatSper complex. Belongs to the heat shock protein 70 family.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: male germ cell nucleus; cell surface; membrane; mitochondrion; synaptonemal complex; nucleus; cytosol

Molecular Function: protein binding; enzyme binding; unfolded protein binding; glycolipid binding; ATP binding

Biological Process: G2/M-specific positive regulation of cyclin-dependent protein kinase activity; male meiosis I; protein refolding; male meiosis; response to unfolded protein; spermatid development