Peptidylprolyl Isomerase D (PPID) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

PPID: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Protein type: Isomerase; Nucleolus; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding; estrogen receptor binding; Hsp70 protein binding; Hsp90 protein binding; transcription factor binding; cyclosporin A binding

Biological Process: release of virus from host; protein transport; positive regulation of viral genome replication; protein peptidyl-prolyl isomerization; positive regulation of protein secretion; protein folding; positive regulation of apoptosis; apoptosis; protein complex assembly; negative regulation of transcription from RNA polymerase II promoter