Kinesin Heavy Chain Member 2a (KIF2A) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

KIF2A: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 5q12-q13

Cellular Component: spindle pole; kinesin complex; centrosome; membrane; spindle microtubule; cytosol

Molecular Function: protein binding; microtubule binding; ATPase activity; motor activity; microtubule motor activity; ATP binding

Biological Process: nervous system development; mitotic spindle organization and biogenesis; metabolic process; cell division; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; mitotic cell cycle; cell differentiation; blood coagulation; microtubule-based movement

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 3