Myosin IXB (MYO9B) Antibody – Rabbit Polyclonal

MYO9B: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; Motor; Motility/polarity/chemotaxis; Actin-binding; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: ruffle; filamentous actin; filopodium tip; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; cell cortex; cytosol; myosin complex; actin cytoskeleton

Molecular Function: calmodulin binding; microfilament motor activity; actin filament binding; ATP-dependent protein binding; protein binding; protein homodimerization activity; zinc ion binding; ATPase activity; ADP binding; actin binding; actin-dependent ATPase activity; ATP binding

Biological Process: monocyte chemotaxis; regulation of small GTPase mediated signal transduction; ARF protein signal transduction; actin filament-based movement; establishment of cell polarity; metabolic process; small GTPase mediated signal transduction; macrophage chemotaxis

Disease: Celiac Disease, Susceptibility To, 4