Heterogeneous Nuclear Ribonucleoprotein D-Like (HNRNPDL) Antibody – Polyclonal

hnRNP D-like: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; DNA-binding; RNA-binding

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: nucleic acid binding; DNA binding; RNA binding; double-stranded DNA binding; nucleotide binding; poly(rG) binding; poly(A) binding; single-stranded DNA binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of gene expression; mRNA metabolic process