Prolactin Regulatory Element Binding (PREB) Antibody – Polyclonal

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

PREB: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Protein type: Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; integral to membrane; nucleus

Molecular Function: DNA binding

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; protein transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unfolded protein response; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification