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UBA6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7049352

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate… More details

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Product Overview

Online Datasheet in PDF
Product Name
UBA6, Polyclonal Antibody
Full Product Name
UBA6 Antibody
Product Gene Name
anti-UBA6 antibody
Product Synonym Names
Ubiquitin-like modifier-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2; UBA6; MOP4; UBE1L2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: UBA6 (MBS7049352)
HRP Conjugated Antibody: UBA6 (MBS7049353)
Matching Pairs
Unconjugated Antibody: UBA6 (MBS7049352)
FITC Conjugated Antibody: UBA6 (MBS7049354)
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Molecular Weight
37,693 Da
OMIM
AY359880 mRNA
3D Structure
ModBase 3D Structure for A0AVT1
Immunogen
Recombinant human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UBA6 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-UBA6 antibody
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry (IHC) of anti-UBA6 antibody

Immunohistochemistry of paraffin-embedded human brain tissue using MBS7049352 at dilution of 1:100
Rabbit Anti-UBA6 Polyclonal Antibody – Cat# MBS7049352

Immunohistochemistry (IHC) of anti-UBA6 antibody

Immunohistochemistry of paraffin-embedded human testicular tissue using MBS7049352 at dilution of 1:100
Rabbit Anti-UBA6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7049352

Immunohistochemistry (IHC) of anti-UBA6 antibody

Immunofluorescent analysis of Hela cells using MBS7049352 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Rabbit Anti-UBA6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7049352

Other Notes

Small volumes of anti-UBA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBA6 purchase

MBS7049352 is an antibody targeting UBA6. Also known as UBA6 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBA6. It may not necessarily be applicable to this product.

NCBI GI #
150417996
NCBI GeneID
55236
NCBI Accession #
NP_060697.4
UniProt Primary Accession #
A0AVT1
UniProt Secondary Accession #
Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9; A6N8M7; B2RAV3
UniProt Related Accession #
A0AVT1
GenBank Nucleotide #
NM_018227.5
NCBI Official Full Name
ubiquitin-like modifier-activating enzyme 6
NCBI Official Synonym Full Names
ubiquitin like modifier activating enzyme 6
NCBI Official Symbol
UBA6
NCBI Official Synonym Symbols
E1-L2; MOP-4; UBE1L2
UniProt Protein Name
Ubiquitin-like modifier-activating enzyme 6
UniProt Synonym Protein Names
Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2
Protein Family
Ubiquitin-like modifier-activating enzyme
UniProt Gene Name
UBA6
UniProt Synonym Gene Names
MOP4; UBE1L2; Ubiquitin-activating enzyme 6; MOP-4; E1-L2
UniProt Entry Name
UBA6_HUMAN
NCBI Protein Information
ubiquitin-like modifier-activating enzyme 6

NCBI Summary for UBA6

Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
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UniProt Comments for UBA6

UBE1L2: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Belongs to the ubiquitin-activating E1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: FAT10 activating enzyme activity; protein binding

Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process
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Research Articles on UBA6

1. Interstitial microdeletions including the chromosome band 4q13.2 and the UBA6 gene as possible causes of intellectual disability and behavior disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBA6 antibody

 Reference Product  PubMed Publications
 UBE2A antibody  >1 publications with UBA6 and UBE2A
 AIPL1 antibody  >1 publications with UBA6 and AIPL1
 UBE2D2 antibody  >1 publications with UBA6 and UBE2D2
 UBE2Z antibody  >1 publications with UBA6 and UBE2Z

Pathways associated with anti-UBA6 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Ubiquitination Pathway antibodies  Protein Ubiquitination Pathway Diagram
 Synthesis Of Active Ubiquitin: Roles Of E1 And E2 Enzymes Pathway antibodies  Synthesis Of Active Ubiquitin: Roles Of E1 And E2 Enzymes Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with anti-UBA6 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with UBA6 and Necrosis
 Embryo Loss Antibodies  >2 publications with UBA6 and Embryo Loss
 Neurobehavioral Manifestations Antibodies  >2 publications with UBA6 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >2 publications with UBA6 and Liver Diseases
 Disease Models, Animal Antibodies  >1 publications with UBA6 and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with UBA6 and Memory Disorders
 Fatty Liver Antibodies  >1 publications with UBA6 and Fatty Liver
 Learning Disorders Antibodies  >1 publications with UBA6 and Learning Disorders
 Liver Neoplasms Antibodies  >1 publications with UBA6 and Liver Neoplasms
 Weight Loss Antibodies  >1 publications with UBA6 and Weight Loss

Organs/Tissues associated with anti-UBA6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with UBA6 and Liver
 Testis Antibodies  >2 publications with UBA6 and Testis
 Brain Antibodies  >2 publications with UBA6 and Brain
 Nerve Antibodies  >1 publications with UBA6 and Nerve
 Ovary Antibodies  >1 publications with UBA6 and Ovary
 Eye Antibodies  >1 publications with UBA6 and Eye
 Lung Antibodies  >1 publications with UBA6 and Lung
 Embryonic Tissue Antibodies  >1 publications with UBA6 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >1 publications with UBA6 and Uncharacterized Tissue
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