Dynamin 1 (DNM1) Antibody – Rabbit Polyclonal

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.

Protein type: EC 3.6.5.5; Hydrolase; Vesicle; Motor; Microtubule-binding; Motility/polarity/chemotaxis

Cellular Component: Golgi apparatus; microtubule; synaptic vesicle; photoreceptor inner segment; cytoskeleton; protein complex; membrane coat; cytoplasm; plasma membrane; synapse; myelin sheath

Molecular Function: GTPase activity; protein dimerization activity; protein C-terminus binding; identical protein binding; protein binding; GTP binding; hydrolase activity; nucleotide binding; protein complex binding; nitric-oxide synthase binding; protein kinase binding; D2 dopamine receptor binding

Biological Process: receptor-mediated endocytosis; sensory perception of sound; G-protein coupled receptor internalization; endosome organization and biogenesis; adult locomotory behavior; receptor internalization; synaptic transmission, GABAergic; endocytosis; protein tetramerization