GTP Binding Protein 4 (GTPBP4) Antibody – Rabbit Polyclonal

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GTPBP4: Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the GTP1/OBG family. NOG subfamily.

Protein type: RNA-binding; Nucleolus; Ribosomal

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: Golgi apparatus; nuclear membrane; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: osteoblast differentiation; negative regulation of cell proliferation; protein stabilization; negative regulation of DNA replication; metabolic process; ribosome biogenesis and assembly; negative regulation of protein ubiquitination; regulation of cyclin-dependent protein kinase activity; negative regulation of cell-cell adhesion; negative regulation of cell migration; negative regulation of collagen binding