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TNFRSF14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9212513

TNFRSF14 is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNFRSF14, Polyclonal Antibody
Full Product Name
TNFRSF14 Antibody (Center)
Product Gene Name
anti-TNFRSF14 antibody
Product Synonym Names
Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This TNFRSF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-236 amino acids from the Central region of human TNFRSF14.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TNFRSF14 peptide (MBS9228012) is used for blocking the activity of TNFRSF14 antibody (MBS9212513)
Molecular Weight
30392
Immunogen Sequence Positions
210-236
OMIM
602746
3D Structure
ModBase 3D Structure for Q92956
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-TNFRSF14 antibody

Cancer; Immunology; Neuroscience; Signal transduction
Applications Tested/Suitable for anti-TNFRSF14 antibody
ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-TNFRSF14 antibody
WB~~1:1000

Western Blot (WB) of anti-TNFRSF14 antibody

Western blot analysis of anti-TNFRSF14 Antibody (Center) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in HL-60 cell line lysate. TNFRSF14 (arrow) was detected using the purified Pab.
Rabbit Anti-TNFRSF14 Polyclonal Antibody – Cat# MBS9212513

Immunohistochemistry (IHC) of anti-TNFRSF14 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with TNFRSF14 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-TNFRSF14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9212513

Flow Cytometry (FC/FACS) of anti-TNFRSF14 antibody

TNFRSF14 Antibody (Center) flow cytometric analysis of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-TNFRSF14 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9212513

Product References and Citations for anti-TNFRSF14 antibody

Dubois,P.C., et.al., Nat. Genet. 42 (4), 295-302 (2010)
Davila,S., et.al., Genes Immun. (2010) In press

Other Notes

Small volumes of anti-TNFRSF14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF14 purchase

MBS9212513 is an antibody targeting TNFRSF14. Also known as TNFRSF14 Antibody (Center). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF14. It may not necessarily be applicable to this product.

NCBI GI #
23200041
NCBI GeneID
8764
NCBI Accession #
NP_003811.2
UniProt Primary Accession #
Q92956
UniProt Secondary Accession #
Q6IB95; Q8N634; Q8WXR1; Q96J31; Q9UM65; B3KW30; B9DI89
UniProt Related Accession #
Q92956
GenBank Nucleotide #
NM_003820.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 14 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 14
NCBI Official Symbol
TNFRSF14
NCBI Official Synonym Symbols
TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 14
UniProt Synonym Protein Names
Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF14
UniProt Synonym Gene Names
HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2
UniProt Entry Name
TNR14_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 14

NCBI Summary for TNFRSF14

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for TNFRSF14

TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Protein type: Cell cycle regulation; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: entry of virus into host cell; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium
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Research Articles on TNFRSF14

1. HVEM may play a critical role in tumor progression and immune evasion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF14 antibody

 Reference Product  PubMed Publications
 BTLA antibody  >72 publications with TNFRSF14 and BTLA
 TNFSF14 antibody  >67 publications with TNFRSF14 and TNFSF14
 TRAF1 antibody  >6 publications with TNFRSF14 and TRAF1
 TRAF2 antibody  >5 publications with TNFRSF14 and TRAF2
 TRAF3 antibody  >2 publications with TNFRSF14 and TRAF3
 TRAF5 antibody  >2 publications with TNFRSF14 and TRAF5

Diseases associated with anti-TNFRSF14 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >287 publications with TNFRSF14 and Necrosis
 Inflammation Antibodies  >39 publications with TNFRSF14 and Inflammation
 Arthritis, Rheumatoid Antibodies  >20 publications with TNFRSF14 and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >9 publications with TNFRSF14 and Nervous System Diseases
 Liver Diseases Antibodies  >9 publications with TNFRSF14 and Liver Diseases
 Neoplasms, Experimental Antibodies  >6 publications with TNFRSF14 and Neoplasms, Experimental
 Atherosclerosis Antibodies  >5 publications with TNFRSF14 and Atherosclerosis
 Anemia Antibodies  >5 publications with TNFRSF14 and Anemia
 Liver Neoplasms Antibodies  >2 publications with TNFRSF14 and Liver Neoplasms
 Kidney Diseases Antibodies  >2 publications with TNFRSF14 and Kidney Diseases

Organs/Tissues associated with anti-TNFRSF14 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >151 publications with TNFRSF14 and Blood
 Bone Antibodies  >15 publications with TNFRSF14 and Bone
 Intestine Antibodies  >13 publications with TNFRSF14 and Intestine
 Liver Antibodies  >11 publications with TNFRSF14 and Liver
 Eye Antibodies  >11 publications with TNFRSF14 and Eye
 Spleen Antibodies  >10 publications with TNFRSF14 and Spleen
 Lymph Node Antibodies  >10 publications with TNFRSF14 and Lymph Node
 Lymph Antibodies  >9 publications with TNFRSF14 and Lymph
 Muscle Antibodies  >7 publications with TNFRSF14 and Muscle
 Ovary Antibodies  >7 publications with TNFRSF14 and Ovary
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