Thioesterase Superfamily Member 4 (THEM4) Antibody – Rabbit Polyclonal

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

CTMP: According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Interacts with AKT1. Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.

Protein type: EC 3.1.2.2

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: mitochondrion; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol

Molecular Function: palmitoyl-CoA hydrolase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; insulin receptor signaling pathway; innate immune response; fatty acid metabolic process