Vacuolar Protein Sorting 54 Homolog (VPS54) Antibody – Rabbit Polyclonal

This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]

VPS54: May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Belongs to the VPS54 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 2p13-p14

Cellular Component: nucleoplasm; Golgi apparatus; perinuclear region of cytoplasm

Molecular Function: protein binding; syntaxin binding

Biological Process: protein transport; neurofilament cytoskeleton organization and biogenesis; homeostasis of number of cells within a tissue; Golgi to vacuole transport; musculoskeletal movement; retrograde transport, endosome to Golgi; growth