Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8) Antibody – Rabbit Polyclonal

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

HSD17B8: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Mitochondrial; EC 1.1.1.62; EC 1.1.1.239; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: mitochondrial envelope; mitochondrial matrix; plasma membrane

Molecular Function: estradiol 17-beta-dehydrogenase activity; protein binding; 3-hydroxyacyl-CoA dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process: androgen metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process