Calcium and Integrin Binding 1 (CIB1) Antibody – Rabbit Polyclonal

CIB1: May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q25.3-q26

Cellular Component: Golgi apparatus; filopodium tip; centrosome; neuron projection; endoplasmic reticulum; nucleoplasm; growth cone; cell soma; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; apical plasma membrane; plasma membrane; nucleus; vesicle; sarcolemma

Molecular Function: protein binding; Ras GTPase binding; protein anchor; calcium ion binding

Biological Process: negative regulation of protein kinase B signaling cascade; apoptosis; negative regulation of microtubule depolymerization; positive regulation of cell adhesion mediated by integrin; positive regulation of metalloenzyme activity; endomitotic cell cycle; positive regulation of cell growth; cytoplasmic microtubule organization and biogenesis; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; cell division; double-strand break repair; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; platelet formation; angiogenesis; positive regulation of cell-matrix adhesion; cell adhesion; regulation of cell division; response to DNA damage stimulus; spermatid development; negative regulation of apoptosis; positive regulation of cell migration