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Zinc Finger, FYVE Domain Containing 9 (ZFYVE9) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS714046

MBS714046 is an antibody targeting ZFYVE9. Also known as Rabbit anti-human zinc finger, FYVE domain containing 9 polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
zinc finger, FYVE domain containing 9 (ZFYVE9), Polyclonal Antibody
Full Product Name
Rabbit anti-human zinc finger, FYVE domain containing 9 polyclonal Antibody
Product Gene Name
anti-ZFYVE9 antibody
Product Synonym Names
zinc finger; FYVE domain containing 9; ZFYVE9; MADHIP; NSP; SARA; SMADIP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
83,721 Da
OMIM
603755
Immunogen
Human ZFYVE9
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8881 / sc-9135
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ZFYVE9 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Other Notes

Small volumes of anti-ZFYVE9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZFYVE9. It may not necessarily be applicable to this product.

NCBI GI #
21618608
NCBI GeneID
9372
NCBI Accession #
AAH32680.1
UniProt Secondary Accession #
Q5T0F6; Q5T0F7; Q9UNE1; Q9Y5R7
UniProt Related Accession #
O95405
NCBI Official Full Name
Zinc finger, FYVE domain containing 9
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 9
NCBI Official Symbol
ZFYVE9
NCBI Official Synonym Symbols
NSP; SARA; MADHIP; SMADIP; PPP1R173
UniProt Protein Name
Zinc finger FYVE domain-containing protein 9
UniProt Synonym Protein Names
Mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; Novel serine protease; NSP; Receptor activation anchor; hSARA; Smad anchor for receptor activation
Protein Family
Zinc finger FYVE domain-containing protein
UniProt Gene Name
ZFYVE9
UniProt Synonym Gene Names
MADHIP; SARA; SMADIP; Madh-interacting protein; NSP; hSARA
UniProt Entry Name
ZFYV9_HUMAN
NCBI Protein Information
zinc finger FYVE domain-containing protein 9; novel serine protease; MADH-interacting protein; smad anchor for receptor activation; protein phosphatase 1, regulatory subunit 173; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor

NCBI Summary for ZFYVE9

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
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UniProt Comments for ZFYVE9

SARA: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: early endosome membrane; early endosome

Molecular Function: protein binding; serine-type peptidase activity; metal ion binding; phosphatidylinositol binding

Biological Process: transforming growth factor beta receptor signaling pathway; endocytosis; SMAD protein nuclear translocation; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; SMAD protein complex assembly
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Research Articles on ZFYVE9

1. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZFYVE9 antibody

 Reference Product  PubMed Publications
 SMURF2 antibody  >1 publications with ZFYVE9 and SMURF2
 SMURF1 antibody  >1 publications with ZFYVE9 and SMURF1
 SMAD2 antibody  >1 publications with ZFYVE9 and SMAD2

Pathways associated with anti-ZFYVE9 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
 SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies  SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram

Organs/Tissues associated with anti-ZFYVE9 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with ZFYVE9 and Pancreas
 Testis Antibodies  >1 publications with ZFYVE9 and Testis
 Liver Antibodies  >1 publications with ZFYVE9 and Liver
 Embryonic Tissue Antibodies  >1 publications with ZFYVE9 and Embryonic Tissue
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