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SNM1/DCLRE1A (DCLRE1A) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420731

MBS420731 is an antibody targeting DCLRE1A. Also known as Goat anti-SNM1/DCLRE1A (internal) Antibody. Reactive in Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SNM1/DCLRE1A, Polyclonal Antibody
Full Product Name
Goat anti-SNM1/DCLRE1A (internal) Antibody
Product Gene Name
Product Synonym Gene Name
SNM1
Product Synonym Names
Goat Anti-SNM1 (C Term) Antibody; DCLRE1A; DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae); HGNC: 17660; KIAA0086; PSO2; SNM1; DNA-crosslink repair gene SNM1; SNM1A; DNA cross-link repair 1A; OTTHUMP00000020516; DCLRE1A antibody; DNA cross-link repair 1A (PSO2 homolog; S. cerevisiae) antibody; HGNC: 17660 antibody; KIAA0086 antibody; PSO2 antibody; SNM1 antibody; DNA-crosslink repair gene SNM1 antibody; SNM1A antibody; DNA cross-link repair 1A antibody; OTTHUMP00000020516 antibody; SNM1 / DCLRE1A (internal)
Immunogen Sequence
PSPNQKRSSQ CKRK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Molecular Weight
116,400 Da
OMIM
609682
Immunogen
Peptide with sequence PSPNQKRSSQCKRK, from the internal region of the protein sequence according to NP_055696.3.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-DCLRE1A antibody
Peptide ELISA (EIA)
Application Notes for anti-DCLRE1A antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx 26kDa band in human duodenum lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117kDa according to NP_055696.2. The 26kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-DCLRE1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DCLRE1A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA cross-link repair 1A protein
NCBI Official Synonym Full Names
DNA cross-link repair 1A
NCBI Official Symbol
DCLRE1A
NCBI Official Synonym Symbols
PSO2; SNM1; SNM1A
UniProt Protein Name
DNA cross-link repair 1A protein
UniProt Synonym Protein Names
SNM1 homolog A; hSNM1; hSNM1A
UniProt Gene Name
DCLRE1A
UniProt Synonym Gene Names
KIAA0086; SNM1; SNM1A; hSNM1; hSNM1A
UniProt Entry Name
DCR1A_HUMAN
NCBI Protein Information
DNA cross-link repair 1A protein

NCBI Summary for DCLRE1A

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
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UniProt Comments for DCLRE1A

DCLRE1A: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus

Molecular Function: 5'-3' exodeoxyribonuclease activity; damaged DNA binding

Biological Process: cell division; double-strand break repair via nonhomologous end joining; mitosis; protection from non-homologous end joining at telomere
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCLRE1A antibody

Pathways associated with anti-DCLRE1A antibody

Diseases associated with anti-DCLRE1A antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >3 publications with DCLRE1A and Anemia

Organs/Tissues associated with anti-DCLRE1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with DCLRE1A and Blood
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