Proto-Oncogene (MET) Antibody – Rabbit Polyclonal

Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Oncoprotein; TK group; Met family

Cellular Component: postsynaptic membrane; extracellular space; neuron projection; cell surface; membrane; cell soma; dendrite; postsynaptic density; cytoplasm; basal plasma membrane; plasma membrane; integral to membrane; excitatory synapse

Molecular Function: nucleotide binding; beta-catenin binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; hepatocyte growth factor receptor activity; protein kinase activity; transferase activity; protein binding; phospholipase binding; protein heterodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; phosphoinositide 3-kinase binding; kinase activity; ATP binding

Biological Process: muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; multicellular organismal development; myoblast proliferation; protein amino acid autophosphorylation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; protein amino acid phosphorylation; positive chemotaxis; endothelial cell morphogenesis; placenta development; regulation of synaptic transmission; skeletal muscle development; positive regulation of mitosis; muscle cell migration; myotube differentiation; hepatocyte growth factor receptor signaling pathway; positive regulation of dendrite morphogenesis; liver development; positive regulation of peptidyl-serine phosphorylation; sperm motility; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; brain development; regulation of excitatory postsynaptic membrane potential; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of DNA replication