Feline Sarcoma Oncogene (FES) Antibody – Rabbit Polyclonal

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.

Protein type: Kinase, protein; EC 2.7.10.2; Oncoprotein; Protein kinase, TK; Tumor suppressor; Protein kinase, tyrosine (non-receptor); TK group; Fer family

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding

Biological Process: regulation of mast cell degranulation; regulation of cell adhesion; epidermal growth factor receptor signaling pathway; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; positive regulation of microtubule polymerization; protein amino acid autophosphorylation; multicellular organismal development; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response