Valyl-Trna Synthetase (VARS) Antibody – Rabbit Polyclonal

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

VARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Protein type: Translation; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; EC 6.1.1.9

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: mitochondrion; cytosol

Molecular Function: valine-tRNA ligase activity; ATP binding

Biological Process: tRNA aminoacylation for protein translation; regulation of translational fidelity; gene expression; valyl-tRNA aminoacylation