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3-Keto-Steroid Reductase (HSD17B7) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717720

MBS717720 is a recombinant protein targeting HSD17B7. Also known as Recombinant Human 3-keto-steroid reductase (HSD17B7). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
3-keto-steroid reductase (HSD17B7), Recombinant Protein
Full Product Name
Recombinant Human 3-keto-steroid reductase (HSD17B7)
Product Synonym Gene Name
HSD17B7; UNQ2563/PRO6243
Product Synonym Names
3-keto-steroid reductase; EC=1.1.1.270; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7; EC=1.1.1.62
Sequence
MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
34,476 Da
Sequence Positions
1-229
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606756
3D Structure
ModBase 3D Structure for P56937
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HSD17B7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
3-keto-steroid reductase
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 7
NCBI Official Symbol
HSD17B7
NCBI Official Synonym Symbols
PRAP; SDR37C1
UniProt Protein Name
3-keto-steroid reductase
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62)
UniProt Gene Name
HSD17B7
UniProt Synonym Gene Names
17-beta-HSD 7
UniProt Entry Name
DHB7_HUMAN
NCBI Protein Information
3-keto-steroid reductase; 17-beta-HSD 7; estradiol 17-beta-dehydrogenase 7; 17beta hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 7; 17 beta-hydroxysteroid dehydrogenase type VII; short chain dehydrogenase/reductase family 37C, member 1

NCBI Summary for HSD17B7

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]

UniProt Comments for HSD17B7

HSD17B7: Responsible for the reduction of the keto group on the C-3 of sterols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - androgen and estrogen; Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; EC 1.1.1.62; EC 1.1.1.270

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane

Molecular Function: estradiol 17-beta-dehydrogenase activity; prolactin receptor binding; 3-keto sterol reductase activity

Biological Process: cholesterol biosynthetic process; estrogen biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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