Protein Tyrosine Phosphatase, Non-Receptor Type 14 (PTPN14) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleus

Molecular Function: protein binding; transcription cofactor activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding

Biological Process: negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lymphangiogenesis; protein amino acid dephosphorylation; regulation of protein export from nucleus

Disease: Choanal Atresia And Lymphedema